Autoimmune etiology of complex regional pain syndrome (M.!Sudeck)
Autoimmune etiology of complex regional pain syndrome (M.!Sudeck)
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DOI：
10.1212/01.wnl.0000143066.58498.ba
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发表时间：
2004-11-09
期刊：
影响因子：
9.9
通讯作者：
Bräu, ME
中科院分区：
文献类型：
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作者：
Blaes, F;Schmitz, K;Bräu, ME
对12例复杂区域性疼痛综合征（CRPS）患者进行血清抗神经系统结构自身抗体检测。免疫组化显示12例患者中有5例（41.6%）存在自主神经系统结构的自身抗体。Western blot分析显示，12例患者中有11例（91.6%）出现神经元反应性。作者假设CRPS可能是交感神经系统的自身免疫过程引起的。
Sera of 12 patients with complex regional pain syndrome ( CRPS) were tested for the occurrence of autoantibodies against nervous system structures. Immunohistochemistry revealed autoantibodies against autonomic nervous system structures in 5 of 12 (41.6%) of the patients. Western blot analysis showed neuronal reactivity in 11 of 12 (91.6%) patients. The authors hypothesize that CRPS can result from an autoimmune process against the sympathetic nervous system.