High-resolution FMRI at 1.5T using balanced SSFP
High-resolution FMRI at 1.5T using balanced SSFP
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DOI：
10.1002/mrm.20753
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Pauly, JM
中科院分区：
文献类型：
--
作者：
Miller, KL;Smith, SM;Pauly, JM
传统的BOLD功能磁共振成像的分辨率比其他磁共振成像方法的分辨率低得多，不足以满足许多重要的应用。在稳健地提高空间分辨率的一个主要困难是在BOLD功能磁共振成像的图像质量差，它遭受失真，模糊，和信号丢失。这项工作考虑了一种新的功能磁共振成像方法的基础上平衡SSFP的分辨率提高的潜力。该方法建立了一种血氧敏感稳态信号，利用平衡SSFP的频率敏感性检测脱氧血红蛋白的频移。BOSS FMRI具有高信噪比效率，并且不会受到图像失真或信号丢失的影响，使该方法成为高分辨率FMRI的优秀候选者。这项研究提出了高分辨率BOSS功能磁共振成像的第一个演示，使用一个有效的3D堆栈分段EPI读出和多个中心频率的联合采集。BOSS FMRI显示在1.5 T下使用标准硬件在视觉和运动系统中实现高分辨率FMRI数据（1 x 1 x 2 mm（3））。目前，BOSS功能磁共振成像的主要局限性是它对时间和空间场漂移的敏感性。
The resolution in conventional BOLD FMRI is considerably lower than can be achieved with other MRI methods, and is insufficient for many important applications. One major difficulty in robustly improving spatial resolution is the poor image quality in BOLD FMRI, which suffers from distortions, blurring, and signal dropout. This work considers the potential for increased resolution with a new FMRI method based on balanced SSFP. This method establishes a blood oxygenation sensitive steady-state (BOSS) signal, in which the frequency sensitivity of balanced SSFP is used to detect the frequency shift of deoxyhemoglobin. BOSS FMRI is highly SNR efficient and does not suffer from image distortions or signal dropout, making this method an excellent candidate for high-resolution FMRI. This study presents the first demonstration of high-resolution BOSS FMRI, using an efficient 3D stack-of-segmented EPI readout and combined acquisition at multiple center frequencies. BOSS FMRI is shown to enable high-resolution FMRI data (1 x 1 x 2 mm(3)) in both visual and motor systems using standard hardware at 1.5 T. Currently, the major limitation of BOSS FMRI is its sensitivity to temporal and spatial field drift.