A selective loss of small‐diameter myelinated optic nerve axons in rats prenatally exposed to ethanol
A selective loss of small‐diameter myelinated optic nerve axons in rats prenatally exposed to ethanol
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DOI：
10.1111/j.1741-4520.2002.tb00861.x
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发表时间：
2002-06
影响因子：
1.3
通讯作者：
K. Sawada;H. Sakata-Haga;S. Komatsu;Kyoko Ohta;Y. Jeong;Y. Fukui
中科院分区：
文献类型：
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作者：
K. Sawada;H. Sakata-Haga;S. Komatsu;Kyoko Ohta;Y. Jeong;Y. Fukui
摘要孕鼠在妊娠10天至21天期间，喂以含酒精的流质饲料。用定量体视学方法对其49日龄产仔的视神经进行了观察。酒精暴露组大鼠的视神经横截面积明显小于对照组。这反映在有髓纤维的数量减少，但没有反映在无髓纤维的数量上。大小分布直方图显示酒精暴露大鼠小轴突直径的有髓纤维数量减少。结果表明，酒精暴露的大鼠视神经发育不良，其特征是选择性丢失小直径的有髓纤维。
ABSTRACT Pregnant rats were fed an ethanol‐containing liquid diet between gestational days 10 and 21. The optic nerves of their litters at 49 days of age were examined using quantitative stereological procedures. Cross‐sectional areas of the optic nerve in ethanol‐exposed rats were significantly smaller than those in controls. This was reflected in the reduced number of myelinated fibers, but not of non‐myelinated fibers. The size distribution histogram indicated a decreased number of small axonal‐diameter myelinated fibers in ethanol‐exposed rats. The results suggested optic nerve hypoplasia hi ethanol‐exposed rats characterized by a selective loss of small‐diameter myelinated fibers.