Hippocampal atrophy in first episode depression: A meta-analysis of magnetic resonance imaging studies
Hippocampal atrophy in first episode depression: A meta-analysis of magnetic resonance imaging studies
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DOI：
10.1016/j.jad.2011.05.057
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发表时间：
2011-11-01
影响因子：
6.6
通讯作者：
Fu, Cynthia H. Y.
中科院分区：
文献类型：
--
作者：
Cole, James;Costafreda, Sergi G.;Fu, Cynthia H. Y.
背景：在重度抑郁障碍患者中，一直可以观察到海马体体积的减少。在复发性和慢性抑郁症患者中，海马体体积减少尤其明显。然而，关于首发抑郁症的报道是混合的。方法：我们进行了随机效应荟萃分析，以确定从疾病开始是否存在海马区萎缩。结果：共有7项研究符合纳入和排除标准，代表了对191名首发抑郁症患者和282名健康对照样本的独立观察。累积分析显示，首发抑郁症患者左侧(标化均数差=-0.41，95%可信区间：[-0.78；-0.03]，z=-2.14，p=0.0321)和右侧(标化均数差=-0.53[-0.98；-0.09]，z=-2.38，p=0.0173)海马区体积均较对照组减少。平均体积缩小左侧为-4.0%，右侧为-4.5%。结论：首发抑郁症患者的海马区体积缩小符合抑郁症的神经发育模型，支持将海马区结构作为抑郁症的潜在神经生物标志物。(C)2011爱思唯尔B.V.保留所有权利。
Background: Reduced hippocampal volume has been consistently observed in major depressive disorder. Hippocampal volume loss is particularly evident in patients with recurrent and chronic depression. However, the reports in first episode depression have been mixed.Methods: We performed a random effects meta-analysis to establish whether hippocampal atrophy exists from disease onset. We included magnetic resonance imaging studies of hippocampal volume in patients with first episode major depressive disorder and matched healthy controls.Results: A total of 7 studies met our inclusion and exclusion criteria, representing independent observations in a total sample of 191 patients and 282 healthy controls. The cumulative analysis revealed hippocampal volume loss in patients with first episode depression relative to controls in both the left (standardised mean difference, SMD = -0.41, 95% Confidence Interval: [-0.78; -0.03], z = -2.14, p = 0.0321) and right (SMD = -0.53[-0.98; -0.09], z = -2.38, p = 0.0173) hippocampi. The average volume reduction was -4.0% in the left and -4.5% in the right hippocampus.Conclusions: Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression. (C) 2011 Elsevier B.V. All rights reserved.