The prefrontal cortex: Response selection or maintenance within working memory?
The prefrontal cortex: Response selection or maintenance within working memory?
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DOI：
10.1126/science.288.5471.1656
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发表时间：
2000-06-02
期刊：
影响因子：
56.9
通讯作者：
Passingham, RE
中科院分区：
文献类型：
--
作者：
Rowe, JB;Toni, I;Passingham, RE
背外侧前额叶皮层是否参与工作记忆中项目的维持或反应的选择是有争议的。我们使用事件相关功能磁共振成像来研究人类在空间工作记忆任务中的表现，我们区分了空间项目的维持和从记忆中选择项目来引导反应。选择，而不是维护，与激活前额叶背外侧区46前额叶皮层，相反，维护与激活前额叶8区和顶内皮层的结果支持的作用，背侧前额叶皮层在选择的代表。ntis解释了这样一个事实，即当受试者在工作记忆任务的项目之间进行选择时，以及当他们在意志行动任务的动作之间自由选择时，该区域都被激活。
It is controversial whether the dorsolateral prefrontal cortex is involved in the maintenance of items in working memory or in the selection of responses. We used event-related functional magnetic resonance imaging to study the performance of a spatial working memory task by humans, We distinguished the maintenance of spatial items from the selection of an item from memory to guide a response. Selection, but not maintenance, was associated with activation of prefrontal area 46 of the dorsal lateral prefrontal cortex, In contrast, maintenance was associated with activation of prefrontal area 8 and the intraparietal cortex The results support a role for the dorsal prefrontal cortex in the selection of representations. ntis accounts for the fact that this area is activated both when subjects select between items on working memory tasks and when they freely select between movements on tasks of willed action.