Relationship between triphasic mechanical properties of articular cartilage and osteoarthritic grade
Relationship between triphasic mechanical properties of articular cartilage and osteoarthritic grade
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关节软骨三相力学特性与骨关节炎分级的关系
DOI：
10.1007/s11427-012-4326-7
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发表时间：
2012-05-01
影响因子：
9.1
通讯作者：
Fan YuBo
中科院分区：
文献类型：
--
作者：
Niu HaiJun;Liu ChengRui;Fan YuBo
本研究旨在探讨不同病理分级的骨关节炎软骨的三相力学特性。首先，对来自患有不同阶段骨关节炎（OA）的兔的软骨样品进行分级。之后，通过肿胀实验使软骨拉紧，并使用高频超声系统测量变化。基于三相模型，将结果与软骨样本的固定电荷密度和水体积分数一起用于估计软骨组织的单轴模量。对于对照软骨样品，软骨表面的单轴弹性模量低于中层和深层。随着OA等级的增加，表层、中层和深层的单轴弹性模量均降低。不同OA级别的软骨表面弹性模量差异有显著性（P<0.01），而1级和2级OA软骨中、深层弹性模量差异无显著性（P> 0.01）。与1级和2级相比，3级OA软骨中、深层的弹性模量显著降低（P<0.05）。总的来说，这项研究可能提供一种新的定量方法来评估OA的严重程度使用软骨组织的力学性能。
The purpose of this study was to explore the triphasic mechanical properties of osteoarthritic cartilage with different pathological grades. First, samples of cartilage from rabbits with different stages of osteoarthritis (OA) were graded. Following this, the cartilage was strained by a swelling experiment, and changes were measured using a high-frequency ultrasound system. The result, together with fixed charge density and water volume fraction of cartilage samples, was used to estimate the uniaxial modulus of the cartilage tissue, based on a triphasic model. For the control cartilage samples, the uniaxial elastic modulus on the cartilage surface was lower than those in the middle and deep layers. With an increase in the OA grade, the uniaxial elastic modulus of the surface, middle and deep layers decreased. A significant difference was found in the surface elastic modulus of different OA grades (P<0.01), while no significant differences were identified for OA cartilages of Grades 1 and 2 in the middle and deep layers (P<0.01). Compared with Grades 1 and 2, there was a significant reduction in the elastic modulus in the middle and deep layers of Grade 3 OA cartilage (P<0.05). Overall, this study may provide a new quantitative method to evaluate the severity of OA using the mechanical properties of cartilage tissue.