Alpha entrainment drives pain relief using visual stimulation in a sample of chronic pain patients: a proof-of-concept controlled study.
Alpha entrainment drives pain relief using visual stimulation in a sample of chronic pain patients: a proof-of-concept controlled study.
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在慢性疼痛患者样本中，阿尔法夹带利用视觉刺激来缓解疼痛：一项概念验证对照研究。
DOI：
10.1097/wnr.0000000000001606
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发表时间：
2021
期刊：
影响因子：
1.7
通讯作者：
Lopez-Diaz K
中科院分区：
文献类型：
--
作者：
Lopez-Diaz K
英国和全世界三分之一的人口都在与慢性疼痛作斗争。通过非侵入性视觉刺激引导大脑阿尔法活动已被证明可以减少健康志愿者的实验疼痛。神经振荡牵引为慢性疼痛患者提供了一种潜在的非侵入性和非药物干预，可以在家中进行，并有可能减少药物的使用。然而，缺乏证据支持它在慢性疼痛患者中的使用。这项研究探讨了(A)阿尔法夹带是否增加了患者的阿尔法能力，以及(B)这种阿尔法能力的增加是否与镇痛有关。总共有28名慢性疼痛患者以舒适的姿势坐着，在随机交叉设计中使用定制的10赫兹(阿尔法)和7赫兹(对照)频率块的护目镜进行了4分钟的视觉刺激。记录刺激前后经络脑电和11分数字评定量表的疼痛强度和疼痛不适评分。脑电分析显示，与7赫兹相比，以10赫兹刺激时，额叶阿尔法功率显著增加。在10 Hz阻滞区，额叶α增加与疼痛强度降低(r=0.33；P<；0.05)和疼痛不适感(r=0.40；P<；0.05)呈显著正相关。这项研究提供了第一个概念的证据，即夹带引起的阿尔法能量的变化与慢性疼痛患者的镇痛反应相关。有必要进行进一步的研究，以调查剂量-反应参数和与药物提供的止痛的等效性。
One-third of the population in the UK and worldwide struggle with chronic pain. Entraining brain alpha activity through noninvasive visual stimulation has been shown to reduce experimental pain in healthy volunteers. Neural oscillations entrainment offers a potential noninvasive and nonpharmacological intervention for patients with chronic pain, which can be delivered in the home setting and has the potential to reduce use of medications. However, evidence supporting its use in patients with chronic pain is lacking. This study explores whether (a) alpha entrainment increase alpha power in patients and (b) whether this increase in alpha correlates with analgesia. In total, 28 patients with chronic pain sat in a comfortable position and underwent 4-min visual stimulation using customised goggles at 10 Hz (alpha) and 7 Hz (control) frequency blocks in a randomised cross-over design. 64-channel electroencephalography and 11-point numeric rating scale pain intensity and pain unpleasantness scores were recorded before and after stimulation. Electroencephalography analysis revealed frontal alpha power was significantly higher when stimulating at 10 Hz when compared to 7 Hz. There was a significant positive correlation between increased frontal alpha and reduction in pain intensity (r= 0.33; P< 0.05) and pain unpleasantness (r= 0.40; P< 0.05) in the 10 Hz block. This study provides the first proof of concept that changes in alpha power resulting from entrainment correlate with an analgesic response in patients with chronic pain. Further studies are warranted to investigate dose–response parameters and equivalence to analgesia provided by medications.