INCREASED INCIDENCE OF BRONCHIAL REACTIVITY IN CHILDREN WITH A HISTORY OF BRONCHIOLITIS
INCREASED INCIDENCE OF BRONCHIAL REACTIVITY IN CHILDREN WITH A HISTORY OF BRONCHIOLITIS
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DOI：
10.1016/s0022-3476(81)80758-5
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发表时间：
1981-01-01
影响因子：
5.1
通讯作者：
LEVISON, H
中科院分区：
文献类型：
--
作者：
GURWITZ, D;MINDORFF, C;LEVISON, H
为评估毛细支气管炎患儿的支气管反应性，对48例毛细支气管炎患儿在入院9年或10年后用乙酰甲胆碱(MCH)激发。同时对肺功能进行评估。在被研究的儿童中，57%的儿童有支气管高反应性。在妇幼保健挑战阳性者的一级亲属中，33%的人有积极的反应。MCH阳性发作的发生与复发性毛细支气管炎病史之间有显著的相关性。肺功能测试显示，阳性反应者的肺流量较低。14名儿童有哮喘或喘息史，但似乎不严重或不频繁，很少需要长期治疗。这些儿童的支气管反应性的流行似乎有很强的遗传成分。支气管高反应性可能是COPD[慢性阻塞性肺疾病]发展的危险因素。
To assess bronchial reactivity in children who had bronchiolitis, 48 children were studied by challenging them with methacholine [MCH] 9 or 10 yr after admission to hospital with bronchiolitis. Pulmonary function was also evaluated. Of the children studied, 57% had bronchial hyperreactivity. Of 1st-degree relatives of those with a positive MCH challenge, 33% had a positive response. There was a significant correlation between the occurrence of a positive MCH challenge and a history of recurrent bronchiolitis. Pulmonary function tests demonstrated lower flow rates in the positive responders. Fourteen children had a history of asthma or wheezing, but this did not appear to be severe or frequent, and few required long-term therapy. There appears to be a strong genetic component in the prevalence of bronchial reactivity in these children. Bronchial hyperreactivity may be a risk factor in the development of COPD [chronic obstructive pulmonary disease].