Surgical and molecular pathology of pancreatic neoplasms.
Surgical and molecular pathology of pancreatic neoplasms.
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DOI：
10.1186/s13000-016-0497-z
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发表时间：
2016-06-07
影响因子：
2.6
通讯作者：
Brosens LA
中科院分区：
文献类型：
--
作者：
Hackeng WM;Hruban RH;Offerhaus GJ;Brosens LA
组织学特征已被证明是非常有用的分类不同类型的胰腺肿瘤。因此，胰腺的主要肿瘤类型一直是根据其显微镜下的外观来分类的。全外显子组测序、基因表达谱和致瘤途径的最新进展加深了我们对胰腺肿瘤潜在生物学的理解。这些进展不仅证实了传统的组织学分类系统，而且为早期诊断和靶向治疗打开了新的大门。本文综述了胰腺导管腺癌、胰腺神经内分泌肿瘤、实体假乳头状瘤、腺泡细胞癌和胰腺母细胞瘤这五种主要胰腺恶性肿瘤的组织病理学、遗传和表观遗传改变以及潜在的治疗靶点。
Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment. This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma.