An Easily Available Ratiometric Reaction-Based AIE Probe for Carbon Monoxide Light-up Imaging
An Easily Available Ratiometric Reaction-Based AIE Probe for Carbon Monoxide Light-up Imaging
复制标题
一种易于使用的基于比例反应的 AIE 探针，用于一氧化碳照明成像
DOI：
10.1021/acs.analchem.9b02691
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发表时间：
2019-08-06
影响因子：
7.4
通讯作者：
Tang, Ben Zhong
中科院分区：
文献类型：
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作者：
Wang, Jianguo;Li, Chunbin;Tang, Ben Zhong
一氧化碳 (CO) 是一种重要的气体递质，可自然调节炎症反应。 CO 原位可视化将有助于揭示其生理/病理功能。不幸的是，大多数现有的 CO 荧光探针都表现出聚集引起的猝灭 (ACQ) 特性。在此，我们报告了具有聚集诱导发射（AIE）特性的基于反应的荧光探针（BTCV-CO），用于CO检测和成像。这种比例 AIE 探针表现出出色的稳定性、高灵敏度（检测限为 30.8 nM）和卓越的选择性。更重要的是，这种 CO 响应 AIE 探针可以方便地设计，并通过两步合成轻松获得，产量高，为生命系统中 CO 的实时可视化提供了易于操作的 AIE 工具箱。
Carbon monoxide (CO) is a significant gasotransmitter that naturally modulates inflammatory responses. Visualization of CO in situ would help to reveal its physiological/pathological functions. Unfortunately, most existing CO fluorescent probes show aggregation-caused quenching (ACQ) properties. Herein, we report the reaction-based fluorescent probe (BTCV-CO) with aggregation-induced emission (AIE) characteristics for CO detection and imaging. This ratiometric AIE probe showed excellent stability, high sensitivity (detection limit of 30.8 nM), and superior selectivity. More importantly, this CO-responsive AIE probe could be facilely designed and easily obtained by two-step synthesis with high yield, providing an easy-to-handle AIE toolbox for real-time visualization of CO in a living system.