A SENSITIVE OPEN-FIELD MEASURE OF ANXIOLYTIC DRUG ACTIVITY
A SENSITIVE OPEN-FIELD MEASURE OF ANXIOLYTIC DRUG ACTIVITY
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DOI：
10.1016/0091-3057(81)90212-4
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发表时间：
1981-01-01
影响因子：
3.6
通讯作者：
BRITTON, KT
中科院分区：
文献类型：
--
作者：
BRITTON, DR;BRITTON, KT
包括地西泮（DZP）、利血平（CDX）、戊巴比妥（PB）和乙醇（EtOH）在内的抗抑郁药物使禁食大鼠的行为产生特定的改变，所述禁食大鼠被给予获得固定在新的开放场环境中心的单个食物颗粒的机会。这些药物增加了在15分钟测试中进食的总量和每次接近食物基座时的平均进食量。后一种效应似乎是抗焦虑药物作用的更敏感的指标，并且在对饲养或梳理没有影响的剂量下发生。DZP在急性或慢性（15天）治疗后有效，剂量对在其饲养笼中测试的禁食大鼠的摄食量无影响。镇静剂苯二氮卓类药物泮的作用与DZP相似，但无统计学意义。在试验前接受额外处理的动物或习惯于开放场地的动物中观察到与DZP相似的行为效应。无论是抗精神病药物氟哌啶醇还是吗啡都不能模仿DZP的作用。
Anxiolytic drugs including diazepam (DZP), chlordiazepoxide (CDX), pentobarbitol (PB) and ethanol (EtOH) produce specific alterations in the behavior of fasted rats that were given access to a single food pellet secured in the center of a novel open field environment. These drugs increase the total amount of food eaten in a 15 min test and the mean amount eaten per approach to the food pedestal. This latter effect appears to be the more sensitive index of anxiolytic drug action and occurs at doses which have no effect on rearing or grooming. DZP was effective following either acute or chronic (15 day) treatment at doses which had no effect on the food consumption by fasted rats tested in their home cages. The effects of the sedative benzodiazepine, flurazepam, were similar to those of DZP but were not statistically significant. Behavioral effects similar to those of DZP were seen in animals receiving additional handling prior to testing, or in animals habituated to the open field. Neither the antipsychotic haloperidol nor morphine mimicked the actions of DZP.