A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
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DOI：
10.1126/science.1117729
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发表时间：
2006-01-06
期刊：
影响因子：
56.9
通讯作者：
Geissmann, F
中科院分区：
文献类型：
--
作者：
Fogg, DK;Sibon, C;Geissmann, F
巨噬细胞和树突状细胞（DC）对于免疫和炎症反应至关重要，属于已称为单核吞噬细胞系统（MPS）的细胞网络。然而，这些细胞的起源和谱系仍然知之甚少。在这里，我们描述了小鼠骨髓祖细胞的分离和克隆分析，该祖细胞特有的单核细胞，几个巨噬细胞亚集和驻留的脾脏DC在体内。也可以通过使用细胞因子巨噬细胞刺激因子和粒细胞巨噬细胞刺激因子来概括体外分化的体外分化。因此，巨噬细胞和DC似乎从一个共同的祖细胞中更新，为MP的概念提供了细胞和分子基础。
Macrophages and dendritic cells (DCs) are crucial for immune and inflammatory responses and belong to a network of cells that has been termed the mononuclear phagocyte system (MPS). However, the origin and lineage of these cells remain poorly understood. Here, we describe the isolation and clonal analysis of a mouse bone marrow progenitor that is specific for monocytes, several macrophage subsets, and resident spleen DCs in vivo. It was also possible to recapitulate this differentiation in vitro by using treatment with the cytokines macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS.