Renal protective effects of resveratrol.
Renal protective effects of resveratrol.
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DOI：
10.1155/2013/568093
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发表时间：
2013
影响因子：
--
通讯作者：
Koya D
中科院分区：
文献类型：
--
作者：
Kitada M;Koya D
白藜芦醇（3，5，4 ′-三羟基芪）是一种天然多酚化合物，存在于葡萄和红酒中，据报道对心血管疾病（包括肾脏疾病）具有有益作用。这些有益的效果被认为是由于这种化合物的抗氧化特性：白藜芦醇是已知的活性氧（ROS）的强大清除剂。除了清除ROS，白藜芦醇还可以通过激活SIRT 1对年龄相关疾病（包括肾脏疾病）具有许多保护作用。SIRT 1是一种NAD+依赖性脱乙酰酶，被鉴定为热量限制延长寿命或延迟年龄相关疾病的分子之一，并且该蛋白质可以通过靶蛋白的脱乙酰化调节多种细胞功能，包括凋亡、线粒体生物发生、炎症、葡萄糖/脂质代谢、自噬和对细胞应激的适应。已有研究表明，白藜芦醇可通过其抗氧化作用或SIRT 1的激活，在动物模型中改善糖尿病肾病、药物性肾损伤、醛固酮性肾损伤、缺血再灌注损伤、脓毒症相关损伤和单侧输尿管梗阻等多种肾损伤。因此，白藜芦醇可能是预防肾损伤的有效补充治疗。
Resveratrol (3,5,4′-trihydroxystilbene), a natural polyphenolic compound found in grapes and red wine, is reported to have beneficial effects on cardiovascular diseases, including renal diseases. These beneficial effects are thought to be due to this compound's antioxidative properties: resveratrol is known to be a robust scavenger of reactive oxygen species (ROS). In addition to scavenging ROS, resveratrol may have numerous protective effects against age-related disorders, including renal diseases, through the activation of SIRT1. SIRT1, an NAD+-dependent deacetylase, was identified as one of the molecules through which calorie restriction extends the lifespan or delays age-related diseases, and this protein may regulate multiple cellular functions, including apoptosis, mitochondrial biogenesis, inflammation, glucose/lipid metabolism, autophagy, and adaptations to cellular stress, through the deacetylation of target proteins. Previous reports have shown that resveratrol can ameliorate several types of renal injury, such as diabetic nephropathy, drug-induced injury, aldosterone-induced injury, ischemia-reperfusion injury, sepsis-related injury, and unilateral ureteral obstruction, in animal models through its antioxidant effect or SIRT1 activation. Therefore, resveratrol may be a useful supplemental treatment for preventing renal injury.