Brief report: Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas.
Brief report: Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas.
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DOI：
10.1056/nejm200007203430305
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发表时间：
2000-07-20
影响因子：
158.5
通讯作者：
Larsen, PR
中科院分区：
文献类型：
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作者：
Huang, SA;Tu, HM;Larsen, PR
血管瘤是婴儿期最常见的肿瘤，一岁儿童的患病率为5%至10%。它们的特征是在出生后第一年迅速生长，随后退化并逐渐退化。1，2我们最近治疗了一名患有巨大肝血管瘤和原发性甲状腺功能减退症的三个月大婴儿，他需要非常高剂量的甲状腺激素来恢复甲状腺功能正常和正常的促甲状腺激素分泌。这一发现表明，甲状腺激素的降解速度加快。我们随后确定了高水平的3型碘甲状腺原氨酸脱碘酶活性的血管瘤组织。这种硒酶通常存在于......
Hemangiomas are the most common tumors of infancy, with a prevalence of 5 to 10 percent among one-year-olds. They are characterized by rapid growth in the first year of life, followed by involution and gradual regression by adolescence.1,2We recently treated a three-month-old infant with massive hepatic hemangiomas and primary hypothyroidism who needed very high doses of thyroid hormone to restore euthyroidism and normal thyrotropin secretion. This finding suggested that the rate of degradation of thyroid hormone was accelerated. We subsequently identified high levels of type 3 iodothyronine deiodinase activity in the hemangioma tissue. This selenoenzyme, normally present in . . .