Sleep Characteristics and Cognitive Function in Older Adults Without Dementia: The CABLE Study
Sleep Characteristics and Cognitive Function in Older Adults Without Dementia: The CABLE Study
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无痴呆症老年人的睡眠特征和认知功能：CABLE 研究
DOI：
10.3233/jad-215017
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发表时间：
2021-01-01
影响因子：
4
通讯作者：
Yu, Jin-Tai
中科院分区：
文献类型：
--
作者：
Fu, Yan;Wang, Zuo-Teng;Yu, Jin-Tai
背景：睡眠特征与认知之间的关系很复杂。阿尔茨海默病（Alzheimer's disease，AD）的病理改变与睡眠特征有关，目的：探讨睡眠特征与认知功能之间的关系，以及AD病理改变在调节睡眠时间与认知功能关系中的作用。共有974名参与者测量了脑脊液（CSF）淀粉样蛋白β（A β）、磷酸化tau（P-tau）、总tau蛋白（T-tau）、认知功能，和睡眠特征来自中国阿尔茨海默氏症生物标志物和生活方式（CABLE）研究。采用线性回归分析探讨睡眠特征与认知的关系。采用非线性回归分析探讨睡眠习惯与认知的关系。结果：匹兹堡睡眠质量指数（PSQI）总分与蒙特利尔认知评估（莫卡）评分呈显著负相关（p = 0.0176）。长潜伏期（p = 0.0054）和低效率（p = 0.0273）与认知障碍相关。午睡行为与较低的莫卡评分相关（p = 0.0045）。睡眠习惯（就寝时间和夜间睡眠时间）与认知之间存在U型关联。因果中介分析表明，P-tau/A β 42介导了睡眠时间与认知功能的关系。结论：睡眠特征与认知功能相关。睡眠习惯（持续时间，就寝时间）与认知有U型关系。AD核心病变可能部分介导睡眠持续时间对认知障碍的影响。
Background: The associations between sleep characteristics and cognition are complicated. Alzheimer's disease (AD) pathologies have been proven to be associated with sleep characteristics.Objective: We aimed to investigate the associations between sleep characteristics and cognitive function and examine the roles of AD pathologies in modulating the association of sleep duration with cognition.Methods: Atotal of 974 participants who had measurements of cerebrospinal fluid (CSF) amyloid-beta (A beta), phosphorylated tau (P-tau), total tau proteins (T-tau), cognitive function, and sleep characteristics were included from the Chinese Alzheimer's Biomarker and Lifestyle (CABLE) study. Linear regression analyses were utilized to explore the associations of sleep characteristics with cognition. Non-linear regression analyses were utilized to explore the associations of sleep habits with cognition. Causal mediation analyses were conducted to explore the mediation effects of AD pathologies on cognition.Results: The Pittsburgh Sleep Quality Index (PSQI) total score was significantly negatively correlated with Montreal Cognitive Assessment (MoCA) score (p = 0.0176). Long latency (p = 0.0054) and low efficiency (p = 0.0273) were associated with cognitive impairment. Habitual nap behavior was associated with lower MoCA scores (p = 0.0045). U-shaped associations were observed between sleep habits (bedtime and nocturnal sleep duration) and cognition. A causal mediation analysis indicated that P-tau/A beta 42 mediated the association of sleep duration with cognition.Conclusion: These findings showed sleep characteristics were associated with cognitive functions. Sleep habits (duration, bedtime) had U-shaped associations with cognition. AD core pathologies might partially mediate the influence of sleep duration on cognitive impairments.