White matter and reading deficits after pediatric traumatic brain injury: A diffusion tensor imaging study.
White matter and reading deficits after pediatric traumatic brain injury: A diffusion tensor imaging study.
复制标题
DOI：
10.1016/j.nicl.2015.10.009
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ewing-Cobbs L
中科院分区：
文献类型：
--
作者：
Johnson CP;Juranek J;Swank PR;Kramer L;Cox CS Jr;Ewing-Cobbs L
儿童创伤性脑损伤通常会导致阅读能力的长期显着缺陷。这项研究旨在确定白质通路，当其受损时，可以预测儿童的阅读缺陷。基于单词阅读的双路径模型，我们预测下额枕束的完整性将与视觉单词识别的性能相关，而上纵向束的完整性将与音素解码的性能相关。假设阅读流畅性和理解力与上纵束、额枕下束和扣带束有关。使用基于束的空间统计数据，白质通路的连通性被用来预测 6 至 16 岁脑外伤儿童 (n = 29) 和骨科损伤儿童 (n = 27) 的阅读缺陷。结果表明，患有脑外伤和上纵束微观结构完整性降低的儿童在视觉单词和音素解码任务中的单词阅读能力下降。此外，患有脑外伤和扣带束微结构变化的儿童阅读流畅度下降。结果支持通过上纵束的背侧通路与视觉词阅读和音位解码之间的关联。未发现额枕下束与视觉单词阅读或音素解码之间存在关联。阅读流畅性与扣带束的完整性有关。这些发现支持使用扩散张量成像预测单词阅读和流畅性的分离途径，并通过指定脑损伤区域来开发获得性阅读缺陷模型，这可以预测从 TBI 急性期恢复后的阅读缺陷。我们将白质和阅读能力模型应用于儿童脑外伤。我们报告了受伤后特定白质通路完整性和特定阅读技能的分离性影响。我们报告了扣带束与阅读能力之间的关系。这些发现的含义是根据与脑损伤相关的基于大脑的阅读模型来讨论的。
Pediatric traumatic brain injury often results in significant long-term deficits in mastery of reading ability. This study aimed to identify white matter pathways that, when damaged, predicted reading deficits in children. Based on the dual-route model of word reading, we predicted that integrity of the inferior fronto-occipital fasciculus would be related to performance in sight word identification while integrity of the superior longitudinal fasciculus would be related to performance in phonemic decoding. Reading fluency and comprehension were hypothesized to relate to the superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and cingulum bundle. The connectivity of white matter pathways was used to predict reading deficits in children aged 6 to 16 years with traumatic brain injury (n = 29) and those with orthopedic injury (n = 27) using tract-based spatial statistics. Results showed that children with traumatic brain injury and reduced microstructural integrity of the superior longitudinal fasciculus demonstrated reduced word-reading ability on sight word and phonemic decoding tasks. Additionally, children with traumatic brain injury and microstructural changes involving the cingulum bundle demonstrated reduced reading fluency. Results support the association of a dorsal pathway via the superior longitudinal fasciculus with both sight word reading and phonemic decoding. No association was identified between the inferior fronto-occipital fasciculus and sight word reading or phonemic decoding. Reading fluency was associated with the integrity of the cingulum bundle. These findings support dissociable pathways predicting word reading and fluency using Diffusion Tensor Imaging and provide additional information for developing models of acquired reading deficits by specifying areas of brain damage which may predict reading deficits following recovery from the acute phase of TBI. We apply models of white matter and reading ability to pediatric brain trauma. We report dissociable effects for integrity of specific white matter pathways and specific reading skills following injury. We report a relationship between the cingulum bundle and reading ability. The implications of these findings are discussed in terms of brain-based reading models as they relate to brain injury.