Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China.
Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China.
复制标题
中国5个主要民族34个X染色体标记的群体遗传学研究。
DOI：
10.1038/srep17711
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发表时间：
2015-12-04
影响因子：
4.6
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Zhang S;Bian Y;Li L;Sun K;Wang Z;Zhao Q;Zha L;Cai J;Gao Y;Ji C;Li C
作为一个多民族国家，中国有一些土著人口群体，他们的文化和社会习俗各不相同，这可能是地理隔离和不同传统的结果。然而，在密切的相互作用和通婚，混合不同的基因库之间的这些种族群体可能会发生。为了更深入地了解这些民族的X染色体遗传背景，我们对中国5个主要民族（汉族、回族、维吾尔族、蒙古族、藏族）的18个X-STR和16个X-Indels进行了基因分型。在汉族、维吾尔族、藏族和蒙古族中共检测到23个私有等位基因。在5个民族中，3个杂合性参数（Ho、He和UHe）均存在显著性差异（p < 0.0001）。在单用X-STR或X-Indels分析和组合分析时，回族-维吾尔族群体的Nei遗传距离最大。系统发育树和主成分分析揭示了回族和维吾尔族的明显的群体分化模式。然而，汉族、藏族和蒙古族群体紧密聚集在一起。与16个X-STR相比，18个X-Indel在5个民族之间表现出总体一致的系统发育信号和相似的聚类。上述结果证实了34个X标记在5个民族中的遗传多态性和遗传潜力。
As a multi-ethnic country, China has some indigenous population groups which vary in culture and social customs, perhaps as a result of geographic isolation and different traditions. However, upon close interactions and intermarriage, admixture of different gene pools among these ethnic groups may occur. In order to gain more insight on the genetic background of X-Chromosome from these ethnic groups, a set of X-markers (18 X-STRs and 16 X-Indels) was genotyped in 5 main ethnic groups of China (HAN, HUI, Uygur, Mongolian, Tibetan). Twenty-three private alleles were detected in HAN, Uygur, Tibetan and Mongolian. Significant differences (p < 0.0001) were all observed for the 3 parameters of heterozygosity (Ho, He and UHe) among the 5 ethnic groups. Highest values of Nei genetic distance were always observed at HUI-Uygur pairwise when analyzed with X-STRs or X-Indels separately and combined. Phylogenetic tree and PCA analyses revealed a clear pattern of population differentiation of HUI and Uygur. However, the HAN, Tibetan and Mongolian ethnic groups were closely clustered. Eighteen X-Indels exhibited in general congruent phylogenetic signal and similar cluster among the 5 ethnic groups compared with 16 X-STRs. Aforementioned results proved the genetic polymorphism and potential of the 34 X-markers in the 5 ethnic groups.