Hepatoblastoma in low birth weight infants: an institutional review
Hepatoblastoma in low birth weight infants: an institutional review
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低出生体重儿的肝母细胞瘤：机构审查
DOI：
10.1007/s00383-004-1292-6
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发表时间：
2004
影响因子：
1.8
通讯作者：
M. Caty
中科院分区：
文献类型：
--
作者：
Stephanie A. Kapfer;M. Petruzzi;M. Caty
肝母细胞瘤和低出生体重之间的关系最近在文献中得到了很好的解释，特别是这些患者可能有一种更具侵袭性的疾病形式。从1989年到2003年，我们的机构治疗了4例出生体重小于1500克的肝母细胞瘤患者。值得注意的是，尽管存在双侧疾病和一例复发性疾病，但患者的生存率为100%。关于这一肝母细胞瘤亚群病因的推测包括氧自由基诱导的发育中的肝细胞损伤。我们的患者普遍患有肺部疾病，需要长时间的补充氧气和呼吸支持。然而，我们的综述不支持低出生体重婴儿的标准护理或肝母细胞瘤患者的管理发生变化。
The association between hepatoblastoma and low birth weight documented recently in the literature has yet to be well explained, in particular the suggestion that these patients may have a more aggressive form of the disease. From 1989 to 2003, our institution treated four patients for hepatoblastoma who had birth weights of less than 1,500 g. Notable was 100% patient survival despite bilateral and, in one case, recurrent disease. Speculation regarding the etiology of this subset of hepatoblastoma has included damage to developing hepatocytes induced by oxygen free radicals. Our patients universally had pulmonary disease requiring prolonged supplemental oxygen and ventilatory support. However, our review supports no changes in the standard care of low birth weight infants or in managing those who develop hepatoblastoma.
影响因子：
9.8
作者：
Medland, Sarah E.;Zayats, Tetyana;Evans, David M.
通讯作者：
Evans, David M.