SKP2 and CKS1 Promote Degradation of Cell Cycle Regulators and Are Associated With Hepatocellular Carcinoma Prognosis
SKP2 and CKS1 Promote Degradation of Cell Cycle Regulators and Are Associated With Hepatocellular Carcinoma Prognosis
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DOI：
10.1053/j.gastro.2009.08.005
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发表时间：
2009-11-01
期刊：
影响因子：
29.4
通讯作者：
Pascale, Rosa M.
中科院分区：
文献类型：
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作者：
Calvisi, Diego F.;Ladu, Sara;Pascale, Rosa M.
背景与目的：细胞周期调节因子P21（WAF 1）、P27（KIP 1）、P57（KIP 2）、P130、RASSF1A和FOXO 1在肝细胞癌（HCC）发病过程中下调。我们研究了泛素连接酶亚基CKS1和SKP2在HCC进展中的作用，它们调节细胞周期调节因子的蛋白酶体降解。方法：来自预后较好（HCCB，>3年生存期）和预后较差（HCCP，
BACKGROUND & AIMS: The cell cycle regulators P21(WAF1), P27(KIP1), P57(KIP2), P130, RASSF1A, and FOXO1 are down-regulated during hepatocellular carcinoma (HCC) pathogenesis. We investigated the role of the ubiquitin ligase subunits CKS1 and SKP2, which regulate proteasome degradation of cell cycle regulators, in HCC progression. METHODS: Human HCC tissues from patients with better (HCCB, >3 years survival) and poorer prognosis (HCCP,