Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms.
Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms.
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DOI：
10.1186/s40409-017-0117-8
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Calvete JJ
中科院分区：
文献类型：
--
作者：
Lomonte B;Calvete JJ
这项工作概述了蛇毒蛋白质组分析的不断发展的策略，并讨论了如何通过不同的实验方法将这些策略结合起来，以期对毒液的成分、毒性和免疫学特征有更全面的了解。总结了该领域的一些最新进展，强调了策略如何从单纯的毒液成分编目（蛋白质组学/毒液组学）发展到对其免疫学（抗毒液组学）和功能（毒毒组学）特征的更广泛探索。总而言之，这些互补策略的结合有助于对毒蛇产生的危及生命的蛋白质混合物建立更广泛、更全面的认识，毒蛇每年导致数千人死亡。
This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achieving a more comprehensive knowledge on the compositional, toxic, and immunological characteristics of venoms. Some recent developments in this field are summarized, highlighting how strategies have evolved from the mere cataloguing of venom components (proteomics/venomics), to a broader exploration of their immunological (antivenomics) and functional (toxicovenomics) characteristics. Altogether, the combination of these complementary strategies is helping to build a wider, more integrative view of the life-threatening protein cocktails produced by venomous snakes, responsible for thousands of deaths every year.