HEPATOCELLULAR-CARCINOMA IN PRIMARY BILIARY-CIRRHOSIS
HEPATOCELLULAR-CARCINOMA IN PRIMARY BILIARY-CIRRHOSIS
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DOI：
10.1016/s0168-8278(05)80307-1
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发表时间：
1994-09-01
影响因子：
25.7
通讯作者：
CHIARAMONTE, M
中科院分区：
文献类型：
--
作者：
FARINATI, F;FLOREANI, A;CHIARAMONTE, M
原发性胆汁性肝硬变被认为是发展为肝细胞癌的低风险因素。我们评估了89名女性原发性胆汁性肝硬变患者和73名不同病因的女性肝硬变患者的肝细胞癌的发生率。患者每6个月进行一次超声和甲胎蛋白检测。在原发性胆汁性肝硬化组和对照组中，分别有两名患者和三名患者发展为肝细胞癌。原发性胆汁性肝硬变患者发生肝细胞癌的相对危险度为0.7。然而，当只考虑IV期的原发性胆汁性肝硬变合并肝硬变时，相对风险实际上是对照组的1.5，每年有1.4%的肝细胞癌病例。这些数据表明，在女性原发性胆汁性肝硬变患者和女性不同病因的肝硬变患者中患肝细胞癌的风险相似。(C)《肝病杂志》。
Primary biliary cirrhosis is considered a low risk for the development of hepatocellular carcinoma. We evaluated the incidence of hepatocellular carcinoma in a cohort of 89 female primary biliary cirrhosis patients and, as a control group, in 73 female patients with cirrhosis of a different etiology. The patients underwent ultrasound and alfa-fetoprotein determination every 6 months. Two patients developed hepatocellular carcinoma in the primary biliary cirrhosis and three in the control group, respectively. The Relative Risk for hepatocellular carcinoma in primary biliary cirrhosis patients was 0.7. However, when considering only stage IV, primary biliary cirrhosis patients with cirrhosis, the Relative Risk was actually 1.5 with respect to controls, with 1.4% cases of hepatocellular carcinoma per year. These data suggest that the risk of hepatocellular carcinoma is similar in female patients with primary biliary cirrhosis and in female patients with cirrhosis of a different etiology. (C) Journal of Hepatology.