Novel inhibitors for histidine decarboxylase from plant components
Novel inhibitors for histidine decarboxylase from plant components
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DOI：
10.18103/ibr.v1i2.1503
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发表时间：
2017-08
期刊：
影响因子：
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通讯作者：
Y. Nitta;H. Kikuzaki;H. Ueno
中科院分区：
文献类型：
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作者：
Y. Nitta;H. Kikuzaki;H. Ueno
摘要 组胺是一种生物活性胺，影响人体内多种生物活性。在这篇综述中，我们讨论了香料和草药中可以抑制组氨酸脱羧酶（HDC）的活性成分，HDC 是一种催化组胺合成的酶。我们通过重组人 HDC 进行抑制测定，筛选了 21 种香料和 122 种药用植物。在香料中，多香果的黄酮苷、槲皮素 3-O-b-D-葡萄糖醛酸 6"-甲酯和槲皮素 3-O (2-O-没食子酰基)葡萄糖苷，1 mM 时分别抑制 HDC 64% 和 55%。在药用植物中，绣线菊的鞣花单宁、rugosin D、rugosin A、 rugosin A 甲酯和tellimagrandin II 显着抑制 HDC，Ki 值约为 0.35-1 mM 这些结果表明植物成分是新型 HDC 抑制剂的有前途的来源。
AbstractHistamine is a bioactive amine that affects a wide range of biological activities in the human body. In this review, we discuss the active components of spices and herbs that can inhibit histidine decarboxylase (HDC), an enzyme that catalyzes synthesis of histamine. We screened 21 spices and 122 medicinal plants by carrying out inhibition assays with recombinant human HDC. Among spices, flavonoid glycosides of allspice, quercetin 3-O-b-D-glucuronide 6"-methyl ester and quercetin 3-O (2-O-galloyl) glucoside, at 1 mM inhibited HDC by 64 and 55%, respectively. Among medicinal plants, ellagitannins of meadowsweet, rugosin D, rugosin A, rugosin A methyl ester, and tellimagrandin II inhibited HDC significantly with Ki values of approximately 0.35-1 mM. These results indicate that plant components are promising sources for novel inhibitors of HDC.