Laser-induced graphene (LIG)-based Au@CuO/V2CTx MXene non-enzymatic electrochemical sensors for the urine glucose test
Laser-induced graphene (LIG)-based Au@CuO/V2CTx MXene non-enzymatic electrochemical sensors for the urine glucose test
复制标题
用于尿糖测试的基于激光诱导石墨烯 (LIG) 的 Au@CuO/V2CTx MXene 非酶电化学传感器
DOI：
10.1016/j.cej.2023.141303
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发表时间：
2023-01-09
影响因子：
15.1
通讯作者：
Zhou, Qin
中科院分区：
文献类型：
--
作者：
Cui, Feiyun;Sun, Haiming;Zhou, Qin
血糖监测对糖尿病患者的健康管理具有重要意义。本文通过在一次性激光诱导石墨烯（LIG）电极表面修饰Au@CuO或Au@CuO/V2 CTx MXene纳米复合材料（NC），研制了非酶葡萄糖传感器。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）和元素分析对产物的结构和形貌进行了表征。采用电化学阻抗谱（EIS）、循环伏安法（CV）和计时电流法（CA）研究了纳米碳的电化学性能。结果表明，Au@CuO/LIG和Au@CuO/V2 CTx MXene/LIG在碱性介质中对葡萄糖氧化具有良好的电催化活性.然而，发现Au@CuO/V2 CTx MXene/LIG容易被氧化。因此，Au@CuO/LIG的组合优选用于葡萄糖测试。在优化的条件下，电化学传感器实现了0.005至5.0 mM的检测范围，灵敏度为1.124 × 106 μ A mM-1 cm-2。响应时间为1.5 s，检测限（LOD）低至1.8 μ M。该传感器具有良好的选择性和稳定性（6周后保持84.12%的活性）。其价格实惠，一次性使用，携带精华液，适合临床应用。我们的研究为非酶葡萄糖传感领域提供了一种新的策略。
Glucose monitoring is of great significance for the health management of diabetic patients. Herein, non-enzymatic glucose sensors were developed by modifying Au@CuO or Au@CuO/V2CTx MXene nanocomposites (NCs) on the surface of disposable laser-induced graphene (LIG) electrode. The structures and morphologies were confirmed by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and elemental analysis. The electrochemical performances of NCs were investigated by electrochemical impedance spectros-copy (EIS), cyclic voltammetry (CV) and chronoamperometry (CA). The results demonstrated that both Au@CuO/LIG and Au@CuO/V2CTx MXene/LIG have excellent electrocatalytic activity for glucose oxidation in an alkaline medium. However, it was found that Au@CuO/V2CTx MXene/LIG was easily oxidized. Hence, the combination of Au@CuO/LIG was preferred for glucose test. Under optimized conditions, the electrochemical sensor achieved a detection range of 0.005 to 5.0 mM with a sensitivity of 1.124 x 106 mu A mM-1 cm-2. The response time was 1.5 s and the limit of detection (LOD) was as low as 1.8 mu M. The sensor has good selectivity and stability (84.12 % activity retained after 6 weeks). Its affordable price, disposable usage and portable essence are suitable for clinical application. Our study presented a novel strategy to the field of non-enzymatic glucose sensing.