Silica particles:: A novel drug-delivery system
Silica particles:: A novel drug-delivery system
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DOI：
10.1002/adma.200400771
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发表时间：
2004-11-04
影响因子：
29.4
通讯作者：
Calleja, G
中科院分区：
文献类型：
--
作者：
Barbé, C;Bartlett, J;Calleja, G
近几十年来，药物输送系统的重大进展使药物管理更加有效。为了将药物递送到特定器官，一系列有机系统（例如，胶束、脂质体和聚合物纳米颗粒）。它们受到限制，包括差的热稳定性和化学稳定性，以及免疫系统的快速消除。相比之下，二氧化硅颗粒提供了一种生物相容性，稳定性和“隐形”的替代品。通过将溶胶-凝胶聚合与喷雾干燥或乳液化学相结合，可以将生物活性分子容易地封装在二氧化硅颗粒内。喷雾干燥面临挑战，包括低产量、表面分离和尺寸限制。相比之下，溶胶-凝胶乳液能够生产具有均匀药物分布的纳米颗粒，并允许环境温度处理，这是处理生物制剂所必需的。可以容易地实现尺寸和释放速率的独立控制。初步的体内实验显示，纳米颗粒的血液稳定性增强，再加上抗肿瘤药物的持续释放，显示出良好的癌症治疗潜力。
In recent decades, significant advances in drug-delivery systems have enabled more effective drug administration. To deliver drugs to specific organs, a range of organic systems (e.g., micelles, liposomes, and polymeric nanoparticles) have been designed. They suffer from limitations, including poor thermal and chemical stability, and rapid elimination by the immune system. In contrast, silica particles offer a biocompatible, stable, and "stealthy" alternative. Bioactive molecules can be easily encapsulated within silica particles by combining sol-gel polymerization with either spray-drying or emulsion chemistry. Spray-drying faces challenges, including low yield, surface segregation, and size limitations. In contrast, sol-gel emulsions enable the production of nanoparticles with homogeneous drug distribution, and permit ambient temperature processing, necessary for handling biologicals. Independent control of the size and release rate can be readily achieved. Preliminary in-vivo experiments reveal enhanced blood stability of the nanoparticles, which, coupled with sustained release of anti-tumor agents, show good potential for cancer treatment.