Differential protracted effects of morphine and ethylketocyclazocine challenges on EEG and behavior in the rat.
Differential protracted effects of morphine and ethylketocyclazocine challenges on EEG and behavior in the rat.
复制标题
吗啡和乙基酮环佐辛挑战对大鼠脑电图和行为的不同长期影响。
DOI：
10.1016/0014-2999(86)90036-1
复制
发表时间：
1986
影响因子：
5
通讯作者：
Khazan,N
中科院分区：
文献类型：
--
作者：
Young,GA;Khazan,N
一组6只成年雌性Sprague-Dawley大鼠连续8天自动静脉注射吗啡。同样，第二组6只大鼠给予乙基酮环辛（EKC）。对照组大鼠长期静脉注射生理盐水。证实吗啡和心电图对脑电图和行为的耐受性。在吗啡戒断后15天，吗啡刺激产生的脑电图和行为麻木平均为5分钟，随后的脑电图和行为唤醒平均为131分钟。相比之下，吗啡刺激的生理盐水对照大鼠产生双相脑电图和行为反应，包括平均85分钟的昏迷，随后平均88分钟的觉醒。然而，在戒断后15天，EKC挑战产生了双相脑电图和行为反应，包括平均57分钟的抑郁和平均55分钟的唤醒；对照盐水大鼠对EKC挑战表现出类似的反应。停药后1个月各组结果相似。因此，长期吗啡治疗的大鼠脑电图和行为的持续影响是明显的，而长期EKC治疗的大鼠则没有。
One group of six adult female Sprague-Dawley rats was given a series of automatically administered i.v. morphine injections over eight days. Similarly, a second group of six rats was given ethylketocyclaxocine (EKC). Control rats received chronic i.v. saline injections. Tolerance to EEG and behavioral effects of morphine and EKC was demonstrated. At 15 days morphine post-withdrawal, morphine challenges produced EEG and behavioral stupor for a mean of 5 min, followed by EEG and behavioral arousal for a mean of 131 min. In contrast, morphine challenges in saline control rats produced a biphasic EEG and behavioral response consisting of a mean of 85 min of stupor, followed by a mean of 88 min of arousal. However, at 15 days EKC post-withdrawal, EKC challenges produced a biphasic EEG and behavioral response consisting of a mean of 57 min of depression followed by a mean of 55 min of arousal; control saline rats demonstrated similar responses to EKC challenges. Similar results were obtained at one month post-withdrawal for all groups. Thus, protracted effects on EEG and behavior were evident in rats chronically treated with morphine, but not in rats chronically treated with EKC.