Biomaterials in regenerative medicine: engineering to recapitulate the natural.
Biomaterials in regenerative medicine: engineering to recapitulate the natural.
复制标题
DOI：
10.1016/j.copbio.2012.01.017
复制
发表时间：
2012-08
影响因子：
7.7
通讯作者：
R. Keatch;A. Schor;J. Vorstius;S. Schor
中科院分区：
文献类型：
--
作者：
R. Keatch;A. Schor;J. Vorstius;S. Schor
细胞外基质（ECM）的功能意义通常被定义为为细胞粘附的结构支持和组织物理完整性的建立。然而，最近的证据导致了一种范式转变，根据这种范式转变，ECM越来越多地被认为对细胞行为产生深远的影响，包括基因表达、迁移和功能稳态的维持。这一重点审查的目的是强调支持这一结论的选定观察结果。最后，我们讨论了再生医学的这些发现的影响，在特定的背景下开发的“下一代”先进的伤口护理设备的临床管理的慢性伤口。
The functional significance of the extracellular matrix (ECM) has generally been defined in terms of the provision of a structural support for cell adhesion and the establishment of tissue physical integrity. Recent evidence has, however, led to a paradigm shift according to which the ECM is increasingly recognised to exert a profound influence on cell behaviour, including gene expression, migration and the maintenance of functional homeostasis. The objective of this focussed review is to highlight selected observations underpinning this conclusion. Finally, we discuss the implications of these findings for regenerative medicine in the specific context of developing the ‘next generation’ of advanced wound care devices for the clinical management of recalcitrant chronic wounds.