Prepregnancy Obesity and a Biobehavioral Predictive Model for Postpartum Depression.
Prepregnancy Obesity and a Biobehavioral Predictive Model for Postpartum Depression.
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DOI：
10.1016/j.jogn.2015.12.013
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Boursaw B
中科院分区：
文献类型：
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作者：
Ruyak SL;Lowe NK;Corwin EJ;Neu M;Boursaw B
检验孕前体重指数（BMI）、孕晚期生物学和行为学变量与产后4周抑郁症状之间关系的预测模型。对妊娠晚期至产后6个月妇女进行的纵向生物行为重复测量研究的次要数据分析。美国中西部和西部城市周围的社区。参与者是111名妇女在怀孕的第三个三个月参加了研究，通过产后4周。全血和唾液用于生物学测量，并且验证的问卷用于行为测量。采用主成分分析和主成分变量的通径分析对模型进行迭代检验。模型中有三个统计学显著的直接影响：从孕前BMI到炎症的路径，从孕前BMI到压力的路径，以及从压力到产后4周抑郁症状的路径。通过干预变量，孕前BMI对产后抑郁症的间接影响没有统计学意义，基于模型的孕前BMI对产后抑郁症的总影响也没有统计学意义。压力与孕前BMI和产后抑郁症有显著联系。这一发现强调了通过减轻压力的预防策略改善母亲，婴儿和家庭结果的持续可能性。
To test a predictive model of the associations among prepregnancy body mass index (BMI), third-trimester biological and behavioral variables, and symptoms of depression at 4 weeks postpartum. Secondary data analysis from a longitudinal, biobehavioral repeated measures study of women during the third trimester of pregnancy through 6 months postpartum. Communities surrounding a midwestern and a western U.S. city. Participants were 111 women enrolled in their third trimesters of pregnancy who were studied through 4 weeks postpartum. Whole blood and saliva were used for biological measures, and validated questionnaires were used for behavioral measures. Principal component analysis and path analysis with principal component variables were used to iteratively test the model. There were three statistically significant direct effects in the model: the path from prepregnancy BMI to inflammation, the path from prepregnancy BMI to stress, and the path from stress to symptoms of depression at 4 weeks postpartum. Indirect effects of prepregnancy BMI on postpartum depression through intervening variables were not statistically significant, nor was the model-based total effect of prepregnancy BMI on postpartum depression. Stress was significantly linked to prepregnancy BMI and postpartum depression. This finding highlights continuing possibilities for improving outcomes for mothers, infants, and families through stress-mitigating preventative strategies.