Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men
Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men
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DOI：
10.1097/mca.0b013e3283647a99
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发表时间：
2013-11
影响因子：
1.8
通讯作者：
S. Maeda;Asako Miyaki;Hiroshi Kumagai;M. Eto;R. So;Kiyoji Tanaka;R. Ajisaka
中科院分区：
文献类型：
--
作者：
S. Maeda;Asako Miyaki;Hiroshi Kumagai;M. Eto;R. So;Kiyoji Tanaka;R. Ajisaka
背景动脉僵硬度增加是心血管疾病的独立危险因素。肥胖者的动脉僵硬度高于非肥胖者。生活方式的改变（即锻炼和饮食改变）可以降低肥胖者的动脉僵硬度。不对称二甲基精氨酸 (ADMA) 是一氧化氮合酶的内源性抑制剂，一氧化氮合酶是负责生成一氧化氮的酶。目的本研究的目的是检查生活方式的改变是否会影响超重和肥胖男性的 ADMA 循环水平，如果影响的话，ADMA 是否参与了生活方式改变导致动脉僵硬度降低的机制。方法 17 名超重和肥胖男性（BMI：29.8±0.8 kg/m2）完成了为期 12 周的生活方式改变计划，其中包括有氧运动和饮食调整。干预前后，我们评估了所有参与者的臂踝脉搏波速度 (baPWV)、动脉僵硬度指数和血浆 ADMA 浓度。结果经过12周的生活方式改变计划后，超重和肥胖男性的BMI和baPWV显着下降，血浆ADMA浓度显着下降。 baPWV 的百分比变化与血浆 ADMA 浓度之间存在显着的正相关性。结论改变生活方式可降低超重和肥胖个体的动脉僵硬度和血浆 ADMA 浓度。动脉僵硬度的降低与血浆 ADMA 浓度的相应降低有关。这些结果表明，ADMA 的减少可能是生活方式改变对动脉僵硬度产生有益影响的重要机制。
BackgroundIncreased arterial stiffness is an independent risk factor for cardiovascular disease. Arterial stiffness is higher in obese individuals than in nonobese individuals. Lifestyle modifications (i.e. exercise and dietary modification) decrease arterial stiffness in obese individuals. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, an enzyme responsible for the generation of nitric oxide. AimThe aim of this study was to examine whether lifestyle modifications affect circulating levels of ADMA in overweight and obese men and, if they do, whether ADMA is involved in the mechanism underlying the decrease in arterial stiffness with lifestyle modification. MethodsSeventeen overweight and obese men (BMI: 29.8±0.8 kg/m2) completed a 12-week lifestyle modification program, which included aerobic exercise and dietary modification. Before and after the intervention, we evaluated brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, and plasma ADMA concentration in all participants. ResultsAfter the 12-week lifestyle modification program, BMI and baPWV decreased significantly and the plasma ADMA concentration decreased markedly in overweight and obese men. There was a significant positive correlation between percent change in baPWV and plasma ADMA concentration. ConclusionLifestyle modifications reduce arterial stiffness and plasma ADMA concentration in overweight and obese individuals. A decrease in arterial stiffness was associated with a corresponding reduction in plasma ADMA concentrations. These results suggest that reductions in ADMA may be an important mechanism underlying the beneficial effect of lifestyle modification on arterial stiffness.