Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development
Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development
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DOI：
10.1016/j.reprotox.2008.10.001
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发表时间：
2009-06-01
影响因子：
3.3
通讯作者：
Abbott, Barbara D.
中科院分区：
文献类型：
--
作者：
Abbott, Barbara D.
过氧化物酶体增殖物激活受体（peroxisome proliferator-activated receptor，PPAR）属于核激素受体超家族，并且有三种主要亚型，即PPAR α、β和γ。这些受体调节影响脂质稳态、炎症、脂肪生成、生殖、伤口愈合和致癌的重要生理过程。这些核受体在生殖和发育中具有重要作用，它们的表达可能影响胚胎对PPAR激动剂的反应。PPARs与全氟烷基酸的生物学效应研究相关，因为这些化合物（包括全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS））会激活PPARalpha。啮齿动物在怀孕期间接触全氟辛酸或全氟辛烷磺酸会导致新生儿死亡、发育迟缓和生长缺陷。对过氧化物酶体增殖物激活受体α基因敲除小鼠的研究表明，全氟辛酸而非全氟辛烷磺酸对发育的影响取决于过氧化物酶体增殖物激活受体α的表达。本文综述了小鼠、大鼠和人类发育过程中PPAR α、β和γ蛋白和mRNA的表达。该综述介绍了许多已发表的研究结果，并按器官系统组织信息，并整理以显示人类，小鼠和大鼠在可比发育阶段的表达模式。介绍了PPAR核受体家族的特点，并讨论了相对于转基因小鼠和成人研究的见解，已知或推断它们在发育中的作用。爱思唯尔公司出版
The peroxisome proliferator-activated receptors (PPAR)belong to the nuclear hormone receptor superfamily and there are three primary subtypes, PPAR alpha, beta, and gamma. These receptors regulate important physiological processes that impact lipid homeostasis, inflammation, adipogenesis, reproduction, wound healing, and carcinogenesis. These nuclear receptors have important roles in reproduction and development and their expression may influence the responses of an embryo exposed to PPAR agonists. PPARs are relevant to the study of the biological effects of the perfluorinated alkyl acids as these compounds, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), activate PPAR alpha. Exposure of the rodent to PFOA or PFOS during gestation results in neonatal deaths, developmental delay and growth deficits. Studies in PPAR alpha knockout mice demonstrate that the developmental effects of PFOA, but not PFOS, depend on expression of PPAR alpha. This review provides an overview of PPAR alpha, beta, and gamma protein and mRNA expression during mouse, rat, and human development. The review presents the results from many published studies and the information is organized by organ system and collated to show patterns of expression at comparable developmental stages for human, mouse, and rat. The features of the PPAR nuclear receptor family are introduced and what is known or inferred about their roles in development is discussed relative to insights from genetically modified mice and studies in the adult. Published by Elsevier Inc.