A Conductance-Based Sensor to Estimate Bladder Volume in Felines.
A Conductance-Based Sensor to Estimate Bladder Volume in Felines.
复制标题
一种基于电导的传感器来估计猫科动物的膀胱体积。
DOI：
10.1109/embc.2018.8512582
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Damaser,MargotS
中科院分区：
文献类型：
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作者：
McAdams,IanS;Majerus,SteveJA;Hanzlicek,Brett;Zorman,Christian;Bourbeau,Dennis;Damaser,MargotS
新的研究工具对于帮助理解下尿路 (LUT) 的神经控制至关重要。对膀胱功能的神经解剖学的更细致的了解可以使新的治疗方案或神经假体来消除失禁。在这里，我们描述了用于下尿路和动态尿动力学的慢性神经生理学研究的无导管液体量估计系统的传感机制的设计、原型制作和验证。该系统由两个刺激电极、一个传感阳极和一个用于控制和记录的微控制器组成。封装的装置足够小，可以通过手术植入膀胱腔内，不会抑制膀胱功能，也不会造成创伤。在模拟膀胱样条件下对电导传感系统进行的台式评估表明，该系统可以预测膀胱内液体体积<； 5 mL 平均误差低于 40 mL，最坏情况平均误差为 13 mL 接近满量程体积。这些结果表明基于电导的膀胱容量感测是实时测量的可行方法。
New research tools are essential to help understand the neural control of the lower urinary tract (LUT). A more nuanced understanding of the neuroanatomy of bladder function could enable new treatment options or neuroprosthesis to eliminate incontinence. Here we describe the design, prototyping and validation of a sensing mechanism for a catheter-free fluid volume estimating system for chronic neurophysiological studies of the lower urinary tract and ambulatory urodynamics. The system consists of two stimulation electrodes, one sensing anode, and a microcontroller for control and recording. The packaged device is small enough to be surgically implanted within the bladder lumen, where it does not inhibit bladder function nor inflict trauma. Benchtop evaluation of the conductance-sensing system in simulated bladder-like conditions has demonstrated that the system can predict intra-vesical fluid volume with <; 5 mL mean error below 40mL and worst-case mean error of 13mL near full-scale volume. These results indicate that conductance-based volume sensing of the urinary bladder is a feasible method for real-time measurement.