Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression
Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression
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DOI：
10.1007/978-3-642-03103-8_1
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Sonenberg, Nahum
中科院分区：
文献类型：
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作者：
Fabian, Marc R.;Sundermeier, Thomas R.;Sonenberg, Nahum
microRNA （miRNA）介导的基因沉默的发现为我们对基因表达转录后控制的理解增加了一个新的复杂性水平。考虑到mirna介导的抑制在基本细胞过程中无处不在，了解其作用机制对于获得生物系统中基因表达调控的清晰图像至关重要。尽管许多miRNA及其靶标已经被确定，但对miRNA作用的详细了解仍然难以捉摸。miRNAs通过翻译抑制和mRNA不稳定在转录后水平调控基因表达。最近的报道表明，许多miRNA效应是通过GW182家族蛋白介导的。本章重点讨论真核生物中mirna调节基因表达的多重和潜在重叠机制。
The discovery of microRNA (miRNA)-mediated gene silencing has added a new level of complexity to our understanding of post-transcriptional control of gene expression. Considering the ubiquity of miRNA-mediated repression throughout basic cellular processes, understanding its mechanism of action is paramount to obtain a clear picture of the regulation of gene expression in biological systems. Although many miRNAs and their targets have been identified, a detailed understanding of miRNA action remains elusive. miRNAs regulate gene expression at the post-transcriptional level, through both translational inhibition and mRNA destabilization. Recent reports suggest that many miRNA effects are mediated through proteins of the GW182 family. This chapter focuses on the multiple and potentially overlapping mechanisms that miRNAs utilize to regulate gene expression in eukaryotes.