Hyperthermia reduces the occurrence of proliferative vitreoretinopathy in a rabbit model.
Hyperthermia reduces the occurrence of proliferative vitreoretinopathy in a rabbit model.
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高温可降低兔模型中增殖性玻璃体视网膜病变的发生率。
DOI：
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发表时间：
1992
影响因子：
4.4
通讯作者：
Masahiro Hiraoka
中科院分区：
文献类型：
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作者：
Nagahisa Yoshimura;Shoji Kuriyama;T. Ohuchi;M. Takemura;Yoshihito Honda;Masahiro Hiraoka
研究了热疗对兔实验性增殖性玻璃体视网膜病变的影响。在成纤维细胞注射后2 ~ 3小时，对视网膜表面进行热处理（42.4℃，30 min）（根据球后间隙温度测量估计），与对照组相比，牵引力性视网膜脱离的发生率降低（P < 0.02），但两组间皱膜形成和牵引力性脱离的发生率无显著差异。在另一项实验中，对正常兔眼进行热处理，只显示视网膜电图b波潜伏期可逆延长，而不影响振幅。组织学检查显示热处理后正常兔视网膜无明显变化。热疗可作为PVR的一种新的治疗手段。
The effects of hyperthermia on experimental proliferative vitreoretinopathy (PVR) in rabbits were studied. Heat treatment (42.4 degrees C for 30 min) of the retinal surface (as estimated from temperature measurement of the retrobulbar space) 2 to 3 hr after fibroblast injection reduced the occurrence of traction retinal detachment compared with control rabbits (P less than 0.02), but the incidence of pucker formation plus traction detachment was not significantly different between the two groups. In a separate experiment, heat treatment applied to normal rabbit eyes showed only reversible elongation in the latency of the electroretinographic b-wave without affecting the amplitude. Histologic examination revealed no significant changes in the heat-treated normal rabbit retina. Hyperthermia may be used as a new therapeutic tool for PVR.