Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women.
Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women.
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血清脂肪酸，去饱和酶活性和腹部肥胖症 - 一项基于人群的研究，对60岁的男性和女性。
DOI：
10.1371/journal.pone.0170684
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Marklund M
中科院分区：
文献类型：
--
作者：
Alsharari ZD;Risérus U;Leander K;Sjögren P;Carlsson AC;Vikström M;Laguzzi F;Gigante B;Cederholm T;De Faire U;Hellénius ML;Marklund M
腹型肥胖是代谢性疾病的一个关键因素。最近的试验表明，膳食脂肪质量会影响腹部脂肪含量，其中棕榈酸和亚油酸对腹部肥胖的影响不同，而n-3多不饱和脂肪酸的影响研究较少。此外，脂肪酸去饱和可能会改变腹部肥胖。我们的目的是在一项基于人群的队列研究中调查血清脂肪酸和去饱和酶与腹型肥胖患病率的横断面相关性。通过气相色谱法测定了60岁男性（n = 1883）和女性（n = 2015）的血清胆固醇酯脂肪酸组成。脂肪酸与腹部肥胖患病率和人体测量指标（例如，矢状腹部直径）分别在多变量调整的逻辑回归模型和线性回归模型中进行评估。采用类似的模型来研究去饱和酶活性（由脂肪酸比率估计）和腹型肥胖之间的关系。在logistic回归分析中，棕榈酸、硬脂酰辅酶A去饱和酶和Δ6去饱和酶指数与腹部肥胖相关;最高与最低四分位数的多变量校正比值比（95%置信区间）分别为1.45（1.19-1.76）、4.06（3.27-5.05）和3.07（2.51-3.75）。亚油酸、α-亚麻酸、二十二碳六烯酸和Δ5-去饱和酶与腹部肥胖呈负相关;多变量校正比值比（95%置信区间）分别为0.39（0.32-0.48）、0.74（0.61-0.89）、0.76（0.62-0.93）和0.40（0.33-0.49）。二十碳五烯酸与腹部肥胖无关。从线性回归模型中获得了类似的结果，该模型评估了与不同人体测量指标的关联。主要观察到n3-多不饱和脂肪酸的性别特异性和线性相关性，而其他暴露的相关性通常是非线性的，并且在不同性别之间相似。根据短期试验的结果，腹部肥胖在棕榈酸比例相对较高的个体中更常见，而亚油酸则相反。进一步的试验应该检查亚油酸及其主要饮食来源，植物油在预防腹部肥胖中的潜在作用。
Abdominal obesity is a key contributor of metabolic disease. Recent trials suggest that dietary fat quality affects abdominal fat content, where palmitic acid and linoleic acid influence abdominal obesity differently, while effects of n-3 polyunsaturated fatty acids are less studied. Also, fatty acid desaturation may be altered in abdominal obesity. We aimed to investigate cross-sectional associations of serum fatty acids and desaturases with abdominal obesity prevalence in a population-based cohort study. Serum cholesteryl ester fatty acids composition was measured by gas chromatography in 60-year old men (n = 1883) and women (n = 2015). Cross-sectional associations of fatty acids with abdominal obesity prevalence and anthropometric measures (e.g., sagittal abdominal diameter) were evaluated in multivariable-adjusted logistic and linear regression models, respectively. Similar models were employed to investigate relations between desaturase activities (estimated by fatty acid ratios) and abdominal obesity. In logistic regression analyses, palmitic acid, stearoyl-CoA-desaturase and Δ6-desaturase indices were associated with abdominal obesity; multivariable-adjusted odds ratios (95% confidence intervals) for highest versus lowest quartiles were 1.45 (1.19–1.76), 4.06 (3.27–5.05), and 3.07 (2.51–3.75), respectively. Linoleic acid, α-linolenic acid, docohexaenoic acid, and Δ5-desaturase were inversely associated with abdominal obesity; multivariable-adjusted odds ratios (95% confidence intervals): 0.39 (0.32–0.48), 0.74 (0.61–0.89), 0.76 (0.62–0.93), and 0.40 (0.33–0.49), respectively. Eicosapentaenoic acid was not associated with abdominal obesity. Similar results were obtained from linear regression models evaluating associations with different anthropometric measures. Sex-specific and linear associations were mainly observed for n3-polyunsaturated fatty acids, while associations of the other exposures were generally non-linear and similar across sexes. In accordance with findings from short-term trials, abdominal obesity was more common among individuals with relatively high proportions of palmitic acid, whilst the contrary was true for linoleic acid. Further trials should examine the potential role of linoleic acid and its main dietary source, vegetable oils, in abdominal obesity prevention.