Mitochondrial transplantation: respiration rescue in respiratory failure.
Mitochondrial transplantation: respiration rescue in respiratory failure.
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线粒体移植：呼吸衰竭的呼吸救援。
DOI：
10.1152/ajplung.00478.2019
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hepokoski,Mark
中科院分区：
文献类型：
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作者：
Hepokoski,Mark
急性肺损伤，更常被称为急性呼吸窘迫综合征35（ARDS），是危重病的毁灭性并发症，全球死亡率为30-50% 36（2）。ARDS的第一个病例是在50多年前描述的，在随后的37年里，我们对相关机制的理解有了许多重要的突破。不幸的是，ARDS的治疗仍然在很大程度上是支持性的;没有经过证实的药物治疗方法存在，迫切需要发现新的治疗靶点。41 42线粒体功能障碍正在成为ARDS的一个可能是可改变的靶点。在过去的十年中，成像和评估线粒体功能的技术的改进已经证明，线粒体功能障碍以多种方式影响肺，而不仅仅是ATP的产生。例如，氧感测、46缺氧性血管收缩和表面活性剂的产生都被发现依赖于健康的线粒体库（9）。已知这些过程在ARDS中受损。Islam等人已经表明，线粒体替代可能是一种有前景的治疗方法，通过证明干细胞通过将健康的线粒体转移到肺泡上皮来减轻肺损伤（3）。51 52
Acute lung injury, more commonly referred to as acute respiratory distress syndrome 35 (ARDS), is a devastating complication of critical illness with a mortality rate of 30-50% 36 worldwide (2). The first cases of ARDS were described over 50 years ago, and in the 37 decades that have followed there have been many important breakthroughs in our 38 understanding of the mechanisms involved. Unfortunately, treatment of ARDS still 39 remains largely supportive; no proven pharmacologic therapies exist, and the discovery 40 of novel therapeutic targets is urgently needed. 41 42Mitochondrial dysfunction is emerging as one such target in ARDS that may be 43 modifiable. Over the past decade, improvements in techniques to image and evaluate 44 mitochondrial function have demonstrated that mitochondrial dysfunction impacts the 45 lung in a multitude of ways beyond ATP production. For example, oxygen sensing, 46 hypoxic vasoconstriction, and surfactant production have all been found to be 47 dependent on a healthy pool of mitochondria (9). These processes are known to be 48 impaired in ARDS. Islam et al. have shown that mitochondrial replacement may be a 49 promising therapeutic approach by demonstrating that stem cells mitigate lung injury via 50 the transfer of healthy mitochondria to the alveolar epithelium (3). 51 52