Spatial cytoskeleton organization is optimized for targeted intracellular cargo transport
Spatial cytoskeleton organization is optimized for targeted intracellular cargo transport
复制标题
空间细胞骨架组织针对靶向细胞内货物运输进行了优化
DOI：
10.1103/physrevlett.117.068101
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
H. Rieger
中科院分区：
文献类型：
--
作者：
K. Schwarz;Y. Schröder;M. Hoth M;H. Rieger
我们考虑随机搜索过程在扩散和弹道运动之间随机交替，其中弹道运动方向的分布函数在空间中逐点变化。方向分布的特定空间依赖性以及两种运动模式之间的切换率建立了空间非均匀搜索策略。我们表明，平均第一次通过时间为几个标准的搜索问题-窄逃逸，反应伴侣的发现，反应逃逸-可以最小化的方向分布，这是让人想起的空间组织的细胞骨架丝的细胞与中心体：从中心到周边和返回的径向弹道传输，以及沿畴界厚度的同心壳层内随机方向的弹道输运。结果表明，活细胞实现有效的搜索策略，通过空间的细胞骨架组织，涉及在中央区域的径向微管，只有一个狭窄的肌动蛋白皮质，而不是充满随机取向的肌动蛋白丝的细胞体，经济地解决各种细胞内运输问题。
We consider random search processes alternating stochastically between diffusion and ballistic motion, in which the distribution function of ballistic motion directions varies from point to point in space. The specific space dependence of the directional distribution together with the switching rates between the two modes of motion establishes a spatially inhomogeneous search strategy. We show that the mean first passage times for several standard search problems—narrow escape, reaction partner finding, reaction escape—can be minimized with a directional distribution that is reminiscent of the spatial organization of the cytoskeleton filaments of cells with a centrosome: radial ballistic transport from the center to the periphery and back, and ballistic transport in random directions within a concentric shell of thicknessalong the domain boundary. The results suggest that living cells realize efficient search strategies for various intracellular transport problems economically through a spatial cytoskeleton organization that involves radial microtubules in the central region and only a narrow actin cortex rather than a cell body filled with randomly oriented actin filaments.
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影响因子：
64.8
作者：
Judy Lieberman
通讯作者：
Judy Lieberman