The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria.
The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria.
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DOI：
10.3389/fimmu.2022.879754
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发表时间：
2022
影响因子：
7.3
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中科院分区：
文献类型：
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慢性自发性荨麻疹（CSU）定义为自发性风团发展和/或血管性水肿的反复发作超过6周，每周至少2次。CSU发病机制的核心环节是肥大细胞、T细胞、嗜酸性粒细胞和其他浸润在病变小静脉周围的免疫细胞的激活。血管通透性增加、血管舒张和炎症细胞的募集直接依赖于肥大细胞介质的释放。复杂的调节系统紧密影响肥大细胞在局部微环境中的关键作用。对Th 2炎症和源自B细胞的自身抗体、嗜碱性粒细胞表达的组胺以及嗜酸性粒细胞或单核细胞启动外源性凝血途径的偏好对肥大细胞产生强大的调节影响。肥大细胞和嗜酸性粒细胞/T细胞之间的细胞间相互作用也是其功能的调节剂，并可能涉及CSU的病理机制。本文综述了肥大细胞与其他免疫细胞之间的相互作用，为CSU的新的研究概念和治疗策略提供了动力。
Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous wheal development and/or angioedema for more than six weeks and at least twice a week. The core link in the pathogenesis of CSU is the activation of mast cells, T cells, eosinophils, and other immune cells infiltrating around the small venules of the lesion. Increased vascular permeability, vasodilatation, and recruitment of inflammatory cells directly depend on mast cell mediators’ release. Complex regulatory systems tightly influence the critical roles of mast cells in the local microenvironment. The bias toward Th2 inflammation and autoantibodies derived from B cells, histamine expressed by basophils, and initiation of the extrinsic coagulation pathway by eosinophils or monocytes exerts powerful modulatory influences on mast cells. Cell-to-cell interactions between mast cells and eosinophils/T cells also are regulators of their function and may involve CSU’s pathomechanism. This review summarizes up-to-date knowledge regarding the crosstalk between mast cells and other immune cells, providing the impetus to develop new research concepts and treatment strategies for CSU.