The influence of placebo administration on the first- night effect in patients with insomnia disorder
The influence of placebo administration on the first- night effect in patients with insomnia disorder
复制标题
安慰剂给药对失眠症患者首夜效应的影响
DOI：
10.1016/j.sleep.2020.03.002
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发表时间：
2020-08-01
期刊：
影响因子：
4.8
通讯作者：
Sun, Hongqiang
中科院分区：
文献类型：
--
作者：
Hu, Sifan;Chen, Jie;Sun, Hongqiang
目的：目的：探讨安慰剂对失眠症患者首夜效应（first-night effect，FNE）的影响。16名失眠症患者接受了两天的安慰剂干预（安慰剂给药组，PL）。20例失眠症患者（非药物组，DF）不给予任何干预。所有参与者都在睡眠实验室接受了连续两晚的多导睡眠图（PSG）测试。结果：与DF组相比，PL组第一个实验室睡眠夜的睡眠起始潜伏期（SOL）、在床时间（TIB）和入睡后觉醒时间（WASO）显著增加，睡眠效率（SE）显著降低（P均< 0.05）。此外，与第二晚相比，PL组第一晚的自报总睡眠时间（TST）较低，主观WASO较强，差异均有统计学意义（均p < 0.05）。然而，没有发现两组之间的N1，N2，N3和REM的持续时间和百分比的显著差异。结论：在失眠症患者中，安慰剂给药可能会增加更差的睡眠的发生，而不会引起N1，N2，N3和REM的持续时间和百分比的第一个睡眠实验室夜晚的变化。在某些情况下，安慰剂可能不起治疗作用，但可能导致反安慰剂效应。(C)2020爱思唯尔B. V.保留所有权利。
Objective: We aimed to investigate the effects of placebo on the first-night effect (FNE) in insomniacs.Methods: In sum, 36 patients with insomnia disorder who met the DSM-5 criteria were enrolled in this study. Sixteen patients with insomnia disorder were given two days of placebo intervention (placebo-administration group, PL). Twenty patients with insomnia disorder (drug-free group, DF) were not given any interventions. All participants underwent two consecutive nights of polysomnographic (PSG) testing in the sleep laboratory. Sleep diaries were recorded during one week at home before the PSG nights and on two subsequent nights.Results: The results demonstrated that compared with the DF group, sleep onset latency (SOL), time in bed (TIB) and wake after sleep onset (WASO) significantly increased and sleep efficiency (SE) significantly decreased in the first sleep lab night in the PL group (all p < 0.05). Moreover, compared with the second night, significant differences were observed in lower self-reported total sleep time (TST) and more subjective WASO during the first night in the PL group (all p < 0.05). However, no significant difference was found in the duration and percentage of N1, N2, N3 and REM between the two groups.Conclusion: In patients with insomnia disorder, placebo administration may increase the occurrence of worse sleep without causing a change in the duration and percentage of N1, N2, N3 and REM on the first sleep lab night. In some cases, a placebo may not serve as treatment but may result in a nocebo effect. (C) 2020 Elsevier B.V. All rights reserved.