CD34+ fibrocytes in normal mitral valves and myxomatous mitral valve degeneration
CD34+ fibrocytes in normal mitral valves and myxomatous mitral valve degeneration
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DOI：
10.1016/j.prp.2005.02.001
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发表时间：
2005-01-01
影响因子：
2.8
通讯作者：
Moosdorf, R
中科院分区：
文献类型：
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作者：
Barth, PJ;Köster, H;Moosdorf, R
我们共调查了15例二尖瓣粘液瘤样变性，并与正常二尖瓣进行比较。在正常二尖瓣中，位于纤维膜和海绵膜中的基质细胞显示小的双极胞质突起，并且被发现为CD 34阳性，这表明与CD 34（+）纤维细胞的密切关系。在粘液瘤样变性的情况下，基质细胞表现出改变的形态，它们表现出多极胞质突起，似乎是增生的，数量增加。本研究首次报道了CD 34（+）纤维细胞构成二尖瓣基质细胞的主要部分。粘液瘤性瓣膜变性发展的主要因素是MMP-9，以及胶原I和III，据报道它们由CD 34（+）纤维细胞分泌。因此，CD 34（+）纤维细胞可能参与粘液瘤性二尖瓣变性的发病机制。(c)2005年Elsevier GmbH。All rights reserved.
We investigated a total of 15 mitral valves with myxomatous degeneration and compared these with normal mitral valves. In normal mitral valves, stromal cells located in the fibrosa and spongiosa showed small bipolar cytoplasmic processes and were found to be positive for CD34, suggesting a close relationship to CD34(+) fibrocytes. In cases of myxomatous degeneration, stromal cells showed an altered morphology in that they exhibited multipolar cytoplasmic processes, appeared to be hyperplastic, and were increased in number. This study is the first to report on CD34(+) fibrocytes making up the majority of mitral valve stromal cells. Major factors in the development of myxomatous valve degeneration are MMP-9, as well as collagen I and III, which have been reported to be secreted by CD34(+) fibrocytes. Therefore, it is likely that CD34(+) fibrocytes are involved in the pathogenesis of myxomatous mitral valve degeneration. (c) 2005 Elsevier GmbH. All rights reserved.