Antibiotic Resistance and Typhoid
Antibiotic Resistance and Typhoid
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DOI：
10.1093/cid/ciy1111
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发表时间：
2019-03-15
影响因子：
11.8
通讯作者：
Dougan, Gordon
中科院分区：
文献类型：
--
作者：
Dyson, Zoe A.;Klemm, Elizabeth J.;Dougan, Gordon
多药耐药（MDR）已成为伤寒等感染性疾病治疗的主要威胁。自20世纪70年代以来，这种威胁在伤寒沙门氏菌血清型中有所增加，部分原因是成功的遗传进化枝的出现，如与MDR表型相关的单倍型H58。H58 S.伤寒可以表达多种抗生素耐药决定簇，同时保留在人群中有效传播和持续存在的能力。近年来，广泛耐药的沙门氏菌的发现也引起了广泛的关注。伤寒只是突出了忽视这一威胁的危险。在这里，我们讨论的演变的S。伤寒耐药表型和考虑管理的选择伤寒仍然是一个主要的全球健康挑战，抗生素耐药性成为治疗和控制的严重威胁。伤寒沙门氏菌的抗生素耐药性的传播，伤寒的原因，是与一个成功的专业分支被称为H58。
Multiple drug (antibiotic) resistance (MDR) has become a major threat to the treatment of typhoid and other infectious diseases. Since the 1970s, this threat has increased in Salmonella enterica serovar Typhi, driven in part by the emergence of successful genetic clades, such as haplotype H58, associated with the MDR phenotype. H58 S. Typhi can express multiple antibiotic resistance determinants while retaining the ability to efficiently transmit and persist within the human population. The recent identification of extensively drug resistant S. Typhi only highlights the dangers of ignoring this threat. Here we discuss the evolution of the S. Typhi MDR phenotype and consider options for management.Typhoid remains a major global health challenge with antibiotic resistance emerging as a serious threat to treatment and control. The spread of antibiotic resistance in Salmonella Typhi, the cause of typhoid, is linked to a successful specialist clade known as H58.