Selective serotonin reuptake inhibitor-induced sexual dysfunction in adolescents: a review.
Selective serotonin reuptake inhibitor-induced sexual dysfunction in adolescents: a review.
复制标题
选择性血清素再摄取抑制剂引起的青少年性功能障碍：综述。
DOI：
10.1097/01.chi.0000131135.70992.58
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Scharko,AlexanderM
中科院分区：
文献类型：
--
作者：
Scharko,AlexanderM
OBJECTIVETo review the existing literature on selective serotonin reuptake inhibitor (SSRI)–induced sexual dysfunction in adolescents.METHODA literature review of SSRI-induced adverse effects in adolescents focusing on sexual dysfunction was done. Nonsexual SSRI-induced adverse effects were compared in adult and pediatric populations. Information regarding SSRI-induced sexual dysfunction was extracted from pediatric SSRI clinical trials, clinical reviews, treatment guidelines, case reports, and MedWatch reports.RESULTSAlthough the incidences of nonsexual SSRI-induced adverse effects seemed to be similar for both adult and pediatric populations, only one male of 1,346 pediatric subjects receiving an SSRI reported sexual dysfunction. Approximately one third of the clinical reviews and treatment guidelines reviewed raised some concern about SSRI-induced sexual dysfunction. In 11 years, only eight MedWatch reports regarding SSRI-induced sexual dysfunction in adolescents have been filed. Only one letter to the editor describing impaired sexual functioning in three of five adolescents on SSRIs could be found.CONCLUSIONSInformation on SSRI-induced sexual dysfunction in adolescents is lacking. Researchers and clinicians may be failing to ask adolescents about sex and sexual functioning in the context of SSRI treatment.
