Toxicological evaluations of cyclopiazonic acid and ochratoxin a in broilers
Toxicological evaluations of cyclopiazonic acid and ochratoxin a in broilers
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DOI：
10.1093/ps/78.10.1380
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发表时间：
1999-10-01
期刊：
影响因子：
4.4
通讯作者：
Edrington, TS
中科院分区：
文献类型：
--
作者：
Gentles, A;Smith, EE;Edrington, TS
以1日龄至3wk龄的Petersen×Hubbard肉鸡为试验对象，研究了赭曲霉毒素A(OA)和环丙酮酸(CPA)对肉鸡的单独作用和联合作用。试验设计为2×2因子，分别为0和2.5 mg OA/kg饲料和0和34 mg CPA/kg饲料处理。对生产性能、血清生化和大体病理观察进行评价。在3wk结束时，联合应用OA、CPA和OA-CPA可减少体重增加(P<；0.05)。赭曲霉毒素A显著增加肾脏的相对重量和血清尿酸和甘油三酯的浓度，并降低总蛋白、白蛋白和胆固醇。CPA的毒性主要表现为腺胃相对重量增加和肌酸激酶活性增加。暴露于OA-CPA的特征是肝脏、肾脏、胰腺和腺胃的相对重量增加，血清白蛋白、总蛋白和胆固醇浓度降低，肌酸激酶活性增加，甘油三酯和尿酸浓度增加。尸检发现，饲喂CPA或OA-CPA的雏鸡可见粘膜增厚，室壁腔扩张。这项研究的数据表明，OA、CPA以及OA-CPA的组合限制了肉鸡的生产性能，并对肉鸡的健康产生了不利影响。在发生相互作用的参数中，化合物的相互作用主要是相加的或少于相加的。
The individual and combined effects of ochratoxin A (OA) and cyclopiazonic acid (CPA) were evaluated in Petersen x Hubbard broiler chickens from 1 d to 3 wk of age. The experimental design was a 2 x 2 factorial with treatments of 0 and 2.5 mg OA/kg feed and 0 and 34 mg CPA/kg feed. Production performance, serum biochemistry, and gross pathological observations were evaluated. Body weight gain was reduced (P < 0.05) by OA, CPA, and OA-CPA in combination at the end of 3 wk. Ochratoxin A significantly increased the relative weight of the kidney and serum concentrations of uric acid and triglycerides and decreased total protein, albumin, and cholesterol. The toxicity of CPA was expressed primarily through increased relative weights of the proventriculus and increased activity of creatine kinase. Exposure to OA-CPA was characterized by increased relative weights of the liver, kidney, pancreas, and proventriculus; decreased concentrations of serum albumin, total protein, and cholesterol; increased activity of creatine kinase; and increased concentrations of triglycerides and uric acid. Postmortem examination revealed that the chickens fed CPA or OA-CPA had thickened mucosa and dilated proventricular lumen. Data from this study demonstrate that OA, CPA, and the OA-CPA combination ran limit broiler performance and adversely affect broiler health. The interaction of the compounds was primarily additive or less than additive in the parameter in which the interaction occurred.