pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media
pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media
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DOI：
10.1039/b815884c
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发表时间：
2009-01-01
期刊：
影响因子：
3.4
通讯作者：
Kataoka, Kazunori
中科院分区：
文献类型：
--
作者：
Kishimura, Akihiro;Liamsuwan, Sittipong;Kataoka, Kazunori
利用动态光散射和激光共聚焦扫描显微镜研究了聚离子复合囊泡（PICsome）的酸性pH敏感性。PICsomes显示pH依赖性和可逆的结构转变，并通过感应酸性pH值的渗透性也经历了变化。在相应的细胞内体的pH值增加的膜渗透性可能是有用的未来应用的PICsomes作为传递载体的生物活性化合物的细胞内室。
The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.