Development of Androgen Recby Application of Ten-vertex p-Carborane as a Novel Hydrophobic Core Structure
Development of Androgen Recby Application of Ten-vertex p-Carborane as a Novel Hydrophobic Core Structure
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应用十顶点对碳硼烷作为新型疏水核心结构开发雄激素回收
DOI：
10.1039/c2md00294a
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hiroyuki Kagechika
中科院分区：
文献类型：
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作者：
Shinya Fujii;Kiminori Ohta;Tokuhito Goto;Akifumi Oda;Hiroyuki Masuno;Ysuyuki Endo;Hiroyuki Kagechika
本文报道了十六面体1，10-二碳基十碳硼烷的新型衍生物的设计、合成、雄激素活性和抗雄激素活性，通常称为十顶碳硼烷。合成的化合物对雄激素受体表现出很高的结合亲和力，并对雄激素依赖的SC-3细胞具有抗雄激素活性。在SC-3实验中，两个化合物也显示了部分激动性活性。碳硼烷衍生物与AR的对接研究表明，十顶碳硼烷有助于开发新的生物活性化合物，以及众所周知的多用途药效团的十二顶碳硼烷。十顶碳硼烷以前没有被应用于药物化学领域，但它似乎具有潜在的疏水性药效团，具有独特的性质。
We report here the design, synthesis, androgenic activity and anti-androgenic activity of novel derivatives of hexadecahedral 1,10-dicarba-closo-decaborane, which is generally called ten-vertex para-carborane. The synthesized compounds exhibited very high binding affinity for the androgen receptor and showed anti-androgenic activity toward the androgen-dependent SC-3 cell line. Two compounds also exhibited partial agonistic activity in SC-3 assay. The docking studies of carborane derivatives to AR demonstrate that ten-vertex carborane is useful for development of novel bioactive compounds as well as twelve-vertex carboranes that are well known to be versatile pharmacophores. Ten-vertex carborane, which has not previously been applied in the field of medicinal chemistry, appears to have potential as a hydrophobic pharmacophore with characteristic properties.