Frontal Alpha Asymmetry in OCD Patients and Unaffected First-Degree Relatives
Frontal Alpha Asymmetry in OCD Patients and Unaffected First-Degree Relatives
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DOI：
10.1037/abn0000283
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发表时间：
2017-08-01
影响因子：
4.6
通讯作者：
Kathmann, Norbert
中科院分区：
文献类型：
--
作者：
Gruetzmann, Rosa;Riesel, Anja;Kathmann, Norbert
额叶脑电图α不对称性作为一个指标的特质方法和特质抑制系统先前已被研究的个体与强迫症（OCD）的混合结果。我们通过调查强迫症患者（n = 113），健康对照参与者（n = 113）和强迫症患者未受影响的一级亲属（n = 37）的大样本，探讨了额叶α不对称作为强迫症的一个可能的危险因素。此外，强迫症症状维度和额叶α不对称性之间的关系进行了探讨。强迫症患者和健康对照参与者在α不对称评分方面没有差异。因此，目前的研究结果不支持强迫症作为一种诊断实体与额叶皮层活动的变化有关的观点。此外，α不对称评分与特定强迫症症状维度无统计学相关性。强迫症的结果不一致的原因进行了讨论，并应在未来的研究中进行探讨。与强迫症患者和健康对照组相比，强迫症患者未受影响的一级亲属显示出左额叶活动增加。这种不对称性以前被发现与压力下的积极情感和适应性情绪调节有关。由于压力性生活事件在强迫症的发病和加重中起着重要作用，因此左额叶活动的增加可能是未受影响的一级亲属的弹性因素。未来的研究应跟进这些结果与纵向风险研究和治疗前和治疗后的评估，以进一步探讨因果关系，这一假定的factor.General Scientific SummaryThis研究发现没有证据表明改变额叶皮质不对称，神经相关的接近回避动机，在强迫症患者。在强迫症患者的未受影响的一级亲属中观察到左额叶活动增加，这与压力下的适应性应对有关，这意味着它可能是强迫症病因的保护因素。
Frontal electroencephalographic alpha asymmetry as an indicator of trait approach and trait inhibition systems has previously been studied in individuals with obsessive-compulsive disorder (OCD) with mixed results. We explored frontal alpha asymmetry as a possible risk factor in OCD by investigating a large sample of OCD patients (n = 113), healthy control participants (n = 113), and unaffected 1st-degree relatives of OCD patients (n = 37). Additionally, the relationship between OCD symptom dimensions and frontal alpha asymmetry was explored. OCD patients and healthy control participants did not differ in alpha asymmetry scores. Hence, the current results do not support the notion that OCD as a diagnostic entity is associated with a shift in frontal cortical activity. Furthermore, alpha asymmetry scores were not statistically related to specific OCD symptom dimensions. Reasons for inconsistent results in OCD are discussed and should be explored in future studies. Compared to OCD patients and healthy control participants, unaffected 1st-degree relatives of OCD patients showed increased left frontal activity. Such asymmetry has previously been found to be associated with positive affect and adaptive emotion regulation under stress. Because stressful life events play an important role in the onset and exacerbation of OCD, increased left frontal activity might serve as a resilience factor in unaffected 1st-degree relatives. Future studies should follow up on these results with longitudinal risk studies and pre- and posttherapy assessments to further explore causality of this putative factor.General Scientific SummaryThis study found no evidence for altered frontal cortical asymmetry, a neural correlate of approach-avoidance motivation, in patients with obsessive-compulsive disorder. Increased left frontal activity, which is linked to adaptive coping under stress, was observed in unaffected first-degree relatives of OCD patients, implying that it might serve as a protective factor in the etiology of obsessive-compulsive disorder.