Tetrazole peptides as copper(II) ion chelators
Tetrazole peptides as copper(II) ion chelators
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DOI：
10.1016/j.ccr.2011.02.023
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发表时间：
2011-08
影响因子：
20.6
通讯作者：
E. Łodyga-Chruścińska
中科院分区：
文献类型：
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作者：
E. Łodyga-Chruścińska
1，5-二取代的四唑环是一个模拟的thecis-amide键是一个独特的元素修改的能力肽螯合铜（II）离子。四唑环系统在肽骨架中的位置在金属肽分子的稳定中起着关键作用。在酰胺基团之间插入四唑导致增强复合物的稳定性并获得非常有效的肽螯合剂。这些发现可以为模拟生物相关的肽金属结合位点提供重要信息。四唑修饰的外源性阿片肽在铜（II）离子的存在下的生物活性的一些方面也提出了在此审查。
The 1,5-disubstituted tetrazole ring a mimetic of thecis-amide bond is an unique element modifying the ability of peptides to chelate copper(II) ions. The position of the tetrazole ring system in the peptide backbone plays a critical role in the stabilization of the metallopeptide molecule. The insertion of a tetrazole between amide groups leads to enhancing the stability of the complex and to obtaining a very effective peptide chelating agent. These findings can provide important information for modeling biologically relevant peptide–metal binding sites. Some aspects of biological activity of tetrazole modified exogenous opioid peptides in the presence of copper(II) ions are also presented in this review.