Laurus nobilis: Composition of Essential Oil and Its Biological Activities.

Laurus nobilis: Composition of Essential Oil and Its Biological Activities.
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DOI:
10.3390/molecules22060930
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发表时间:
2017-06-03
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
De Feo V
De Feo V
中科院分区:
其他
文献类型:
--
作者:
Caputo L;Nazzaro F;Souza LF;Aliberti L;De Martino L;Fratianni F;Coppola R;De Feo V

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月桂树原产于地中海南部地区,主要在欧洲和美国作为观赏和药用植物种植。通过 GC 和 GC-MS 研究了从意大利南部采集的 L. nobilis 叶子中提取的精油 (EO) 的化学成分。总共鉴定出55种化合物,占精油总量的91.6%。主要成分为1,8-桉叶素(31.9%)、桧烯(12.2%)、芳樟醇(10.2%)。体外测定了 EO 和 1,8-桉树脑的抗菌和抗真菌活性。我们评估了 EO 对 SH-SY5Y 细胞系的细胞毒性,以及 EO 对腺苷酸环化酶 1 (ADCY1) 表达的影响,表明精油可能对中枢神经系统有影响。
Laurus nobilis is native to the southern Mediterranean region and cultivated mainly in Europe and the USA as an ornamental and medicinal plant. The chemical composition of the essential oil (EO) from leaves of L. nobilis, collected in Southern Italy, was studied by GC and GC-MS. In all, 55 compounds were identified, accounting for 91.6% of the total essential oil. 1,8-Cineole (31.9%), sabinene (12.2%), and linalool (10.2%) were the main components. Antimicrobial and antifungal activities of EO and 1,8-cineole were determined in vitro. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line, as well as the influence of the EO on the expression of adenylate cyclase 1 (ADCY1), suggesting possible essential oil effects on the Central Nervous System.
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