Reasons for risk-reducing mastectomy versus MRI-screening in a cohort of women at high hereditary risk of breast cancer
Reasons for risk-reducing mastectomy versus MRI-screening in a cohort of women at high hereditary risk of breast cancer
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DOI：
10.1016/j.breast.2011.01.006
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发表时间：
2011-06-01
期刊：
影响因子：
3.9
通讯作者：
Warner, Ellen
中科院分区：
文献类型：
--
作者：
Haroun, Iman;Graham, Tracy;Warner, Ellen
目的：为了确定原因，激励妇女在一个队列中的妇女进行乳腺癌的密切监测，以减少风险的乳房切除术（RRM）。患者和方法：BRCA1或BRCA2突变的妇女谁是在一个基于MRI的乳腺癌筛查研究有资格参加这项调查。一个自我管理的问卷调查给妇女谁做，谁没有终止年度MRI为基础的监测，以进行RRM。调查问卷包括家族史、风险认知和筛查满意度等信息。此外，妇女被要求提供的主要原因，他们的选择有预防性手术或没有，并询问他们的满意度与此choice.Results：246名妇女没有乳腺癌参加了这项研究。其中，39名妇女（16%）在开始筛查后的某个时候选择了RRM。虽然有母亲或姐妹患乳腺癌的妇女比没有受影响的一级亲属的妇女更有可能选择RRM（21%对10%），但这并没有达到统计学意义。认为自己患乳腺癌的风险大于50%的女性比估计自己的风险小于50%的女性更有可能选择RRM（19%对6%）。对癌症的恐惧是选择RRM的最常见原因（38%的受访者）其次是以前患过癌症（25%），然后是关心他们的孩子（16%）。在参加基于MRI的筛查项目的BRCA突变女性中，对个人乳腺癌风险的高感知和一级亲属的乳腺癌病史是决定进行RRM的预测因素。(C)2011年由Elsevier Ltd.出版
Objective: To determine the reasons that motivate women in a cohort of women under intensive surveillance for breast cancer to undergo risk-reducing mastectomy (RRM).Patients and methods: Women with a BRCA1 or BRCA2 mutation who were enrolled in an MRI-based breast screening study were eligible to participate in this survey. A self-administered questionnaire was given to women who did, and who did not terminate annual MRI-based surveillance in order to undergo RRM. The questionnaire included information on family history, risk perception and satisfaction with screening. In addition, women were asked to provide the principal reason for their choice of having preventive surgery or not, and were asked about their satisfaction with this choice.Results: 246 women without breast cancer participated in the study. Of these, 39 women (16%) elected to have RRM at some point after initiating screening. Although women who had a mother or sister with breast cancer were more likely to opt for RRM than were women with no affected first-degree relative (21% versus 10%) this did not reach statistical significance. Women who perceived their breast cancer risk to be greater than 50% were more likely to opt for RRM than were women who estimated their risk to be less than 50% (19% versus 6%). Fear of cancer was the most common reason cited for choosing to have RRM (38% of respondents) followed by having had a previous cancer, (25%), then concern over their children (16%).Conclusion: Among women with a BRCA mutation who are enrolled in an MRI-based screening program, a high perception of personal breast cancer risk and a history of breast cancer in a first-degree relative are predictors of the decision to have RRM. (C) 2011 Published by Elsevier Ltd.