Release of glial tissue-specific proteins after acute stroke - A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein
Release of glial tissue-specific proteins after acute stroke - A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein
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DOI：
10.1161/01.str.31.11.2670
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发表时间：
2000-11-01
期刊：
影响因子：
8.3
通讯作者：
Lamers, KJB
中科院分区：
文献类型：
--
作者：
Herrmann, M;Vos, P;Lamers, KJB
背景与目的：本研究旨在比较分析急性脑卒中患者血清胶质原纤维酸性蛋白（GFAP）和S-100B蛋白的浓度。方法：对32例脑卒中症状与血管供应前区脑缺血一致的患者进行研究。入院后和中风发作后4天内采集静脉血样。以颅脑CT资料为基础，评估脑梗死区域的形态和体积。出院时采用美国国立卫生研究院卒中量表（NIHSS）和Barthel指数评分对患者的临床状况进行连续评价。结果：蛋白S-100B与GFAP释放量呈显著相关(r=0.96
Background and Purpose-This study was aimed at the comparative analysis of serum concentrations of glial fibrillary acidic protein (GFAP) and protein S-100B in patients with acute stroke.Methods-We investigated 32 patients with stroke symptoms consistent with cerebral ischemia in the anterior territory of vascular supply. Serial venous blood samples were taken after admission to the hospital and during the first 4 days after onset of stroke. Evaluation of lesion topography and volume of infarcted brain area was based on cranial CT data. The patients' clinical status was consecutively evaluated by the National Institutes of Health Stroke Scale (NIHSS) and the Barthel Index score at discharge from the hospital.Results-Protein S-100B and GFAP release was found to be significantly correlated (r=0.96; P