Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation.
Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation.
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DOI：
10.1111/nyas.13360
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发表时间：
2017-06
影响因子：
5.2
通讯作者：
Nusrat A
中科院分区：
文献类型：
--
作者：
Garcia-Hernandez V;Quiros M;Nusrat A
肠道上皮形成一种高度动态和选择性的屏障，控制液体和溶质的吸收，同时限制病原体进入底层组织。屏障特性是通过细胞间连接实现的，细胞间连接包括顶端紧密连接(TJ)和邻近的粘连连接和桥粒。TJ Tetraspan claudin蛋白在上皮细胞之间形成毛孔，控制细胞旁液体和离子移动。除了对屏障功能的调节外，Claudin家族成员还控制着上皮细胞的动态平衡，并以时空方式在肠道和隐窝-腔轴表达。这种微妙的生理性差异克劳丁蛋白表达平衡在黏膜炎症过程中会发生改变。炎症介质影响转录调节，以及内吞转运、靶向和在TJ中保留Claudins。在肠炎性疾病中，肠上皮细胞claudin-1、-2和-18的表达增加，而claudin-3、-4、-5、-7、-8和-12的表达下调。Claudin蛋白的这种变化除了影响上皮和粘膜的动态平衡外，还改变了上皮屏障的功能。更好地了解控制上皮claudin蛋白的调控机制将为加强炎症性疾病的上皮屏障功能和恢复粘膜内稳态提供策略。
The intestinal epithelium forms a highly dynamic and selective barrier that controls absorption of fluid and solutes while restricting pathogen access to underlying tissues. Barrier properties are achieved by intercellular junctions that include an apical tight junction (TJ) and subjacent adherens junction and desmosomes. The TJ tetraspan claudin proteins form pores between epithelial cells to control paracellular fluid and ion movement. In addition to regulation of barrier function, claudin family members control epithelial homeostasis and are expressed in a spatiotemporal manner in the intestinal and crypt-luminal axis. This delicate balance of physiologic differential claudin protein expression is altered during mucosal inflammation. Inflammatory mediators influence transcriptional regulation, as well as endocytic trafficking, targeting, and retention of claudins in the TJ. Increased expression of intestinal epithelial claudin-1, -2, and -18, with downregulation of claudin-3, -4, -5, -7, -8, and -12, has been observed in intestinal inflammatory disorders. Such changes in claudin proteins modify the epithelial barrier function in addition to influencing epithelial and mucosal homeostasis. An improved understanding of the regulatory mechanisms that control epithelial claudin proteins will provide strategies to strengthen the epithelial barrier function and restore mucosal homeostasis in inflammatory disorders.
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影响因子：
3.7
作者：
Bhat AA;Sharma A;Pope J;Krishnan M;Washington MK;Singh AB;Dhawan P
通讯作者：
Dhawan P
DOI：
10.1038/nrgastro.2010.39
发表时间：
2010-05
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.5
作者：
Colegio, OR;Van Itallie, C;Anderson, JM
通讯作者：
Anderson, JM
影响因子：
5.5
作者：
Angelow, S;Kim, KJ;Yu, ASL
通讯作者：
Yu, ASL
影响因子：
3.7
作者：
Al-Sadi R;Ye D;Boivin M;Guo S;Hashimi M;Ereifej L;Ma TY
通讯作者：
Ma TY