Cu(II)−Azabis(oxazoline) Complexes Immobilized on Magnetic Co/C Nanoparticles: Kinetic Resolution of 1,2-Diphenylethane-1,2-diol under Batch and Continuous-Flow Conditions
Cu(II)−Azabis(oxazoline) Complexes Immobilized on Magnetic Co/C Nanoparticles: Kinetic Resolution of 1,2-Diphenylethane-1,2-diol under Batch and Continuous-Flow Conditions
复制标题
DOI：
10.1021/cm9019099
复制
发表时间：
2010-01
影响因子：
8.6
通讯作者：
A. Schaetz;R. Grass;Quirin M. Kainz;W. Stark;O. Reiser
中科院分区：
文献类型：
--
作者：
A. Schaetz;R. Grass;Quirin M. Kainz;W. Stark;O. Reiser
利用铜（I）催化的叠氮化物/炔环加成（CuAAC）反应，用氮杂双（恶唑啉）−铜（II）络合物标记碳包覆的钴纳米颗粒，并测试所得纳米磁性催化剂在通过不对称单苯甲酰化动力学拆分外消旋1，2-二苯基乙烷-1，2-二醇中的功效。在间歇条件下和在连续流动型反应器中考察了新型半多相催化剂。钴核的极高铁磁性不仅有助于通过间歇反应中的磁性倾析回收纳米珠，而且还能够实现新颖的连续流动反应器设计：这进一步允许有效搅拌和容纳颗粒，而无需复杂的分离策略，如纳滤。
Carbon coated cobalt nanoparticles were tagged with azabis(oxazoline)−copper(II) complexes utilizing a copper(I)-catalyzed azide/alkyne cycloaddition (CuAAC) reaction, and the efficacy of the resulting nanomagnetic catalyst was tested in the kinetic resolution of racemic 1,2-diphenylethane-1,2-diol via asymmetric monobenzoylation. The novel semiheterogeneous catalyst was examined under batch conditions and in a continuous flow-type reactor. The extremely high ferromagnetism of the cobalt cores not only facilitates the recycling of the nanobeads via magnetic decantation in the batch reactions but also enables a novel continuous flow-reactor design: This further allowed efficient agitation and containment of the particles to occur without the need for sophisticated separation strategies such as nanofiltration.